Plasma homocysteine and the methylenetetra-hydrofolate reductase C677T gene variant:: lack of association with schizophrenia
Plasma homocysteine and the methylenetetra-hydrofolate reductase C677T gene variant:: lack of association with schizophrenia
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DOI：
10.1097/00001756-199907130-00008
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发表时间：
1999-07-13
期刊：
影响因子：
1.7
通讯作者：
Vilella, E
中科院分区：
文献类型：
--
作者：
Virgos, C;Martorell, L;Vilella, E
甲基碳代谢紊乱导致高同型半胱氨酸血症，与精神分裂症有关。亚甲基四氢叶酸还原酶（MTHFR）基因编码一种与高同型半胱氨酸血症相关的不耐热酶，其T677等位基因的纯合性在精神分裂症患者中增加。我们调查了是否血浆同型半胱氨酸浓度和C677 T MTHFR变异的频率增加精神病医院住院精神分裂症患者（n = 210）与对照组（n = 218）相比。血浆同型半胱氨酸浓度在精神分裂症组和对照组之间无显著性差异。两组T等位基因和TT基因型频率分布相似（40%和15%）。这些结果表明，受损的同型半胱氨酸代谢不太可能在精神分裂症。NeuroReport 10：2035-2038（C）1999 Lippincott威廉姆斯和威尔金斯。
DISTURBANCES in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased in schizophrenic patients. We have investigated whether plasma homocysteine concentration and the frequency of C677T MTHFR variant were increased in schizophrenic inpatients of a psychiatric hospital (n = 210) compared with controls (n = 218). There were no significant differences in plasma homocysteine concentrations between the schizophrenia and the control group. The distributions of T allele and TT genotype frequencies were similar in both groups (40% and 15%). These results show that impaired homocysteine metabolism is unlikely in schizophrenia. NeuroReport 10:2035-2038 (C) 1999 Lippincott Williams & Wilkins.