Metabolism of endogenous and xenobiotic substances by pulmonary vascular endothelial cells.
Metabolism of endogenous and xenobiotic substances by pulmonary vascular endothelial cells.
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肺血管内皮细胞对内源性和外源性物质的代谢。
DOI：
10.1016/0163-7258(89)90037-5
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发表时间：
1989
影响因子：
13.5
通讯作者：
Grantham,CJ
中科院分区：
文献类型：
--
作者：
Ryan,US;Grantham,CJ
无论是内源性的还是由人引入到循环中的，在心输出量中递送的所有物质在进入体循环之前必须穿过肺。因此，肺相对于血液传播物质处于战略性位置。尽管其横截面外观脆弱（图1），但肺内皮已被证明具有高度代谢活性，并能够处理各种循环生物活性物质，包括肽、胺、胰高血糖素、核苷酸和脂质（图2）。这些反应中的大多数是由于与位于肺内皮细胞腔表面的酶相互作用而发生的（Ryan，1985，1986 a，B）。此外，许多药物、麻醉剂和合成物质通过肺循环降解、运输或以其他方式去除。在过去10年中出现了许多综述，涵盖了可归因于内皮的肺代谢功能的几个特征（Ryan和Ryan，1977; Ryan，1985，1986 a，B; Fishman和Pietra，1974）。我们的目标只是扩大一些较新的领域，以及我们认为值得特别注意的领域。当然，许多被内皮包裹的物质也对内皮细胞具有有效的作用（通常是受体介导的），并导致内皮衍生的生物活性产物的释放。例如，缓激肽、凝血酶和ATP导致EDRF、PGI和PAF的释放，所有这些物质对其他细胞类型都具有强大的作用。
Whether endogenous or introduced into the circulation by man, all substances delivered in the cardiac output must traverse the lungs before entering the systemic circulation. Thus, the lungs are strategically situated with respect to blood-borne substances. Despite its fragile cross-sectional appearance (Fig. 1) the pulmonary endothelium has been shown to be highly metabolically active and to be capable of processing a wide variety of circulating bioactive substances including peptides, amines, prostaglandins, nucleotides and lipids (Fig. 2). Most of these reactions occur as a result of interaction with enzymes situated on the luminal surface of pulmonary endothelial cells (Ryan, 1985, 1986a, b). In addition, a number of drugs, anesthetics and synthetic substances are degraded, transported or otherwise removed by the pulmonary circulation. A number of reviews have appeared in the last 10 years, covering several features of the metabolic functions of the lungs that can be attributed to endothelium (Ryan and Ryan, 1977; Ryan, 1985, 1986a, b; Fishman and Pietra, 1974). It is our aim only to enlarge on some of the newer areas and those we feel deserve special attention. Of course many of the substances that are inactivate by endothelium also have potent actions (frequently receptor-mediated) on endothelial cells and lead to the release of endothelium-derived bioactive products. For example bradykinin, thrombin and ATP lead to the release of EDRF, PGI and PAF, all substances with powerful actions on other cell types.