Basal nitric oxide synthesis in essential hypertension
Basal nitric oxide synthesis in essential hypertension
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DOI：
10.1016/s0140-6736(96)07631-3
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发表时间：
1997-03-22
期刊：
影响因子：
168.9
通讯作者：
Benjamin, N
中科院分区：
文献类型：
--
作者：
Forte, P;Copland, M;Benjamin, N
背景 有间接证据表明高血压患者血管内皮细胞中一氧化氮（NO）的合成发生了改变。本研究的目的是通过测量无机硝酸盐的合成来更直接地估计未经治疗的原发性高血压患者的一氧化氮生成量，无机硝酸盐是人体一氧化氮氧化的最终产物。在高血压患者和适当的健康对照中进行了两项独立的研究。(1)方法在第一项研究中，10名患者和13名对照者每天给予82μmol硝酸盐饮食，连续2天，第2天进行尿和血浆硝酸盐测量以及24小时动态血压监测。在第二项研究中，11 名患者和 11 名对照者在吸收后状态进行了研究； 10 分钟内静脉注射 200 mg L-[N-15](2) 精氨酸。进行了 24 小时动态血压监测，并在接下来的 36 小时内进行了完整的尿液收集。结果在第一项研究中，高血压患者的 24 小时尿硝酸盐排泄量低于对照组（平均每 24 小时 450 [SEM 37] vs 760 mumoles [77]；p
Background There is indirect evidence that nitric oxide (NO) synthesis in vascular endothelium of patients with hypertension is altered. The aim of this study was to estimate more directly NO production in patients with untreated essential hypertension by measurement of synthesis of inorganic nitrate, which is the end product of NO oxidation in humans. Two separate studies were undertaken in patients with hypertension and appropriate healthy controls.(1)Methods In the first study, ten patients and 13 controls were given a diet containing 82 mu moles nitrate per day for 2 days, with urinary and plasma nitrate measurement and 24 h ambulatory blood pressure monitoring on the 2nd day. In the second study, 11 patients and 11 controls were studied in the postabsorptive state; a bolus of 200 mg L-[N-15](2) arginine was administered intravenously over 10 min. 24 h ambulatory blood pressure monitoring was done and complete urine collections were made for the next 36 h.Findings In the first study, 24 h urinary nitrate excretion was lower in the hypertensive patients than in the control group (mean 450 [SEM 37] vs 760 mu moles [77] per 24 h; p