Ethnic differences in microvascular function in apparently healthy South African men and women
Ethnic differences in microvascular function in apparently healthy South African men and women
复制标题
表面健康的南非男性和女性微血管功能的种族差异
DOI：
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复制
发表时间：
2014
影响因子：
2.7
通讯作者：
Estelle V. Lambert
中科院分区：
文献类型：
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作者：
P. Pienaar;Lisa K. Micklesfield;Lisa K. Micklesfield;Jason M.R. Gill;Angela C. Shore;K. Gooding;Naomi S. Levitt;Estelle V. Lambert
这项研究的中心问题是什么？众所周知，不同种族之间的心血管疾病结局存在差异。不同种族的健康青年男女之间的微血管功能是否存在种族差异？本研究使用激光多普勒成像和离子导入乙酰胆碱和硝普钠，比较不同种族之间的微血管功能，并了解皮肤电阻在这种方法中的作用。主要发现及其重要性是什么？在非洲黑人和混合血统人群中，校正皮肤阻力后，内皮依赖性微血管功能仍然减弱，这表明平滑肌功能的差异可能是导致疾病风险种族差异的重要因素。
What is the central question of this study? It is well recognized that there are disparities in cardiovascular disease outcomes between ethnic groups. Are there ethnic differences in microvascular function between healthy, young men and women of different ethnicities? This study used laser Doppler imagery and iontophoresis of acetylcholine and sodium nitroprusside to compare microvascular function between different ethnic groups and to understand the role of skin resistance in this methodology. What is the main finding and its importance? Endothelium‐independent microvascular function remained attenuated after correcting for skin resistance in the Black African and mixed ancestry groups, suggesting that differences in smooth muscle function may be an important factor contributing to ethnic differences in disease risk.
DOI：
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发表时间：
2011
期刊：
--
影响因子：
--
作者：
A. Alwan
通讯作者：
A. Alwan