ETIOLOGY AND MORTALITY OF STATUS EPILEPTICUS IN CHILDREN - A RECENT UPDATE
ETIOLOGY AND MORTALITY OF STATUS EPILEPTICUS IN CHILDREN - A RECENT UPDATE
复制标题
DOI：
10.1001/archneur.1989.00520370076023
复制
发表时间：
1989-01-01
影响因子：
--
通讯作者：
SHANAHAN, RJ
中科院分区：
文献类型：
--
作者：
PHILLIPS, SA;SHANAHAN, RJ
我们回顾了1983年至1987年间入院的193名儿童的218次癫痫持续状态的病历。在这些事件中，61%为男孩，39%为女孩，年龄范围为1个月至14岁（平均3.2岁）。大多数发作（73%）发生在5岁以下的患者中，其中61%小于3岁，28%小于1岁。71%的发作以癫痫持续状态为初始发作。在1岁以下的患者中，75%的发作与急性原因有关（28%为细菌性脑膜炎，30%为电解质紊乱），23%为特发性（19%与发热有关），在小于3岁的儿童中，47%的发作有急性原因，9%有先前已知的癫痫发作障碍，32%为特发性（30%伴发热）。在3岁以上的患者中，28%的发作与急性原因有关，38%为已知癫痫，13%为特发性（11%有发热）。总死亡率为6%，其中1%的发作在发作期间死亡。我们的结论是癫痫持续状态的病因是与年龄有关，急性原因是更常见的患者年龄较小的介绍。当我们的数据与其他大型儿童研究相比，似乎与癫痫持续状态相关的死亡率有所下降。
We reviewed the medical records of 218 episodes of status epilepticus in 193 children who were admitted to the hospital between 1983 and 1987. Of the episodes, 61% were in boys and 39% in girls, with an age range of 1 month to 14 years (average, 3.2 years). The majority of episodes (73%) occurred in patients who were less than 5 years old, with 61% less than 3 years old and 28% less than 1 year old. Status epilepticus as the initial seizure occurred in 71% of episodes. In patients under 1 year of age, 75% of episodes were associated with acute causes (bacterial meningitis in 28% and electrolyte disorders in 30%), and 23% were idiopathic (19% associated with fever) in children less than 3 years old, 47% of episodes had an acute cause, 9% had a previously known seizure disorder, and 32% were idiopathic (30% associated with fever). In patients older than 3 years, 28% of episodes were associated with acute causes, 38% were known epileptics, and 13% were idiopathic (11% had fevr). Overall mortality was 6%, with 1% of all episodes ending in death during the presenting seizure. We conclude that the etiology of status epilepticus is age related, with acute causes being more common in patients with a younger age at presentation. When our data are compared with other large studies in children, it appears that mortality associated with status epilepticus has decreased.