Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment
Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment
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DOI：
10.1016/j.neurobiolaging.2018.08.024
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发表时间：
2018-12-01
影响因子：
4.2
通讯作者：
Verret, Laure
中科院分区：
文献类型：
--
作者：
Cattaud, Vanessa;Bezzina, Charlotte;Verret, Laure
最近的研究结果表明，阿尔茨海默病(AD)患者的小白蛋白(PV)中间神经元功能受损，这种功能受损可能与网络功能障碍和记忆障碍有关。PV细胞通常与一种特定的细胞外基质--神经周网络(PNN)相关联。PNNS被认为可以保护PV细胞的完整性，而淀粉样变性是否会影响PNNS尚不清楚。在这里，我们评估了在疾病的不同阶段，Tg2576 AD小鼠模型中有和没有PNNS的海马区PV细胞的数量。在3月龄的Tg2576中，我们发现在CA1、CA2和CA3区的PV+和/或PV+/PNN+细胞缺失。重要的是，短暂暴露在丰富的环境中，这已被证明对AD受试者的记忆具有长期的有益影响，拯救了PV/PNN细胞数量缺陷。我们的结论是，丰富的环境对AD模型小鼠的认知改善可能是通过重建海马PV细胞网络及其PNN来支持的。(C)2018 Elsevier Inc.保留所有权利。
Recent findings show that parvalbumin (PV) interneuron function is impaired in Alzheimer's disease (AD), and that this impairment in PV function can be linked to network dysfunction and memory deficits. PV cells are often associated with a specific extracellular matrix, the perineuronal net (PNN). PNNs are believed to protect PV cell integrity, and whether the amyloidopathy affects PNNs remains unclear. Here, we evaluated the number of PV cells with and without PNNs in the hippocampus of the Tg2576 mouse model of AD at different stages of the disease. We show a deficit of PV+ and/or PV+/PNN+ cells in the areas CA1, CA2, and CA3 in Tg2576 as young as 3 months of age. Importantly, transient exposure to an enriched environment, which has proven long-lasting beneficial effects on memory in AD subjects, rescues the PV/PNN cell number deficits. We conclude that cognitive improvements induced by enriched environment in AD mouse models could be supported by a remodeling of hippocampal PV cell network and their PNNs. (C) 2018 Elsevier Inc. All rights reserved.