Wnt Pathway Regulation of Embryonic Stem Cell Self-Renewal
Wnt Pathway Regulation of Embryonic Stem Cell Self-Renewal
复制标题
DOI：
10.1101/cshperspect.a007971
复制
发表时间：
2012-09-01
影响因子：
7.2
通讯作者：
Merrill, Bradley J.
中科院分区：
文献类型：
--
作者：
Merrill, Bradley J.
胚胎干细胞（ESC）可以产生成体生物体中发现的所有细胞类型。值得注意的是，即使在体外多次细胞分裂后，只要培养条件阻止细胞分化，它们仍保留这种能力。 Wnt 信号传导和 β-连环蛋白已被证明对 ESC 产生强烈影响，既可以刺激干细胞的扩增，也可以刺激向谱系定型细胞类型的分化。 Wnt 信号传导在 ESC 中的不同作用，以及这些作用背后有时非常规的机制，已经引起了关于 Wnt 信号传导在多能干细胞中的作用的大量争议和好奇。通过检查 Wnt 信号传导对自我更新与分化看似相反的作用的原因，可以深入了解干细胞中 Wnt 功能的机制。
Embryonic stem cells (ESCs) can generate all of the cell types found in the adult organism. Remarkably, they retain this ability even after many cell divisions in vitro, as long as the culture conditions prevent differentiation of the cells. Wnt signaling and beta-catenin have been shown to cause strong effects on ESCs both in terms of stimulating the expansion of stem cells and stimulating differentiation toward lineage committed cell types. The varied effects of Wnt signaling in ESCs, alongside the sometimes unconventional mechanisms underlying the effects, have generated a fair amount of controversy and intrigue regarding the role of Wnt signaling in pluripotent stem cells. Insights into the mechanisms of Wnt function in stem cells can be gained by examination of the causes for seemingly opposing effects of Wnt signaling on self-renewal versus differentiation.