Unethical not to Investigate Radiotherapy for COVID-19
Unethical not to Investigate Radiotherapy for COVID-19
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DOI：
10.1177/1559325820950104
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发表时间：
2020-07-01
期刊：
影响因子：
2.5
通讯作者：
Mortazavi, S. M. J.
中科院分区：
文献类型：
--
作者：
Cuttler, Jerry M.;Bevelacqua, Joseph J.;Mortazavi, S. M. J.
布恩等人在《初步非伤害信》中敦促谨慎并仔细检查COVID-19患者低剂量放疗的证据和后勤工作。这正是3月份提出的要求，也是自2020年4月下旬埃默里大学医院Winship癌症研究所批准第一个I/II期临床试验以来发生的情况。研究人员在第7天中期结果的预印本中得出结论，“在一项对5名患有COVID-19肺炎的氧依赖患者进行的小型试点试验中，低剂量全肺放射治疗导致临床状态、脑病和放射学浸润迅速改善，而没有急性毒性或细胞因子风暴恶化。低剂量全肺放疗似乎是安全的，显示出早期疗效的承诺，并保证更大的前瞻性试验。“另一项临床试验的初步结果也给出了类似的结果。总之，作者认为，不研究放射疗法作为治疗COVID-19引起的肺炎的潜在疗法是不道德的。
The primum non nocere letter by Boon et al. urged caution and careful examination of the evidence and logistics of low-dose radiotherapy in COVID-19 patients. This is exactly what was requested in March and what has occurred since late April 2020 when the first phase I/II clinical trial was approved at the Winship Cancer Institute, Emory University Hospital. The preprint of day-7 interim results by the investigators concluded, "In a small pilot trial of 5 oxygen-dependent patients with COVID-19 pneumonia, low-dose whole-lung radiation led to rapid improvement in clinical status, encephalopathy, and radiographic infiltrates without acute toxicity or worsening the cytokine storm. Low-dose whole-lung radiation appears to be safe, shows early promise of efficacy, and warrants larger prospective trials." Preliminary results from another clinical trial gave similar results. In conclusion, the authors believe it would be unethical not to investigate radiotherapy as a potential remedy against COVID-19 induced pneumonia