Human papillomavirus and anal neoplasia.
Human papillomavirus and anal neoplasia.
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DOI：
10.1007/s11904-008-0013-5
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发表时间：
2008-05-01
影响因子：
4.6
通讯作者：
Palefsky, Joel
中科院分区：
文献类型：
--
作者：
Palefsky, Joel
肛门癌在一般人群中是一种罕见的疾病，但肛门癌的发病率在某些高危人群中较高，例如男男性行为者（MSM）和免疫抑制个体，包括艾滋病毒感染者。在艾滋病毒阳性的男男性行为者中，肛门癌的发病率可能比一般妇女人群中宫颈癌的发病率高出10倍。肛门癌与人乳头瘤病毒（HPV）感染有关，并且可能在高度肛门上皮内瘤变（HGAIN）之前发生。HGAIN和肛门HPV感染在肛门癌风险人群中均高度流行。目前的问题包括确定抗逆转录病毒治疗对HGAIN自然史和肛门癌发病率的影响，优化HGAIN的诊断和治疗方法，以及确定预防性HPV疫苗预防高危人群肛门HPV感染和肛门癌的潜力。
Anal cancer is a rare disease in the general population, but the incidence of anal cancer is higher in certain at-risk groups, such as men who have sex with men (MSM), and immunosuppressed individuals, including those with HIV infection. Among HIV-positive MSM, the incidence of anal cancer may be as high as 10 times greater than current rates of cervical cancer in the general population of women. Anal cancer is associated with human papillomavirus (HPV) infection and may be preceded by high-grade anal intraepithelial neoplasia (HGAIN). HGAIN and anal HPV infection are both highly prevalent in groups at risk for anal cancer. Current issues include determining the effect of antiretroviral therapy on the natural history of HGAIN and the incidence of anal cancer, optimizing diagnostic and therapeutic approaches to HGAIN, and determining the potential for prophylactic HPV vaccines to prevent anal HPV infection and anal cancer in at-risk groups.