Effects of adrenergic and cholinergic agents upon insulin secretion in vitro.
Effects of adrenergic and cholinergic agents upon insulin secretion in vitro.
复制标题
肾上腺素能和胆碱能药物对体外胰岛素分泌的影响。
DOI：
10.1210/endo-80-5-975
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发表时间：
1967
期刊：
影响因子：
4.8
通讯作者：
James Ashmore
中科院分区：
文献类型：
--
作者：
Willy Malaisse;F. Malaisse;PETER H. Wright;James Ashmore
肾上腺素能药物（肾上腺素、去甲肾上腺素和异丙肾上腺素）抑制用葡萄糖（150 mg/100 ml）孵育的大鼠胰腺碎片的胰岛素分泌。这种抑制作用似乎是通过α受体介导的，因为它被α-阻断剂阻断，但几乎不受β-阻断剂的影响。胆碱能药物（乙酰胆碱和氨甲酰基胆碱）在含有低浓度（100 mg/100 ml）葡萄糖的培养基中具有兴奋作用，同时加入阿托品可以抑制这种作用。这些观察结果表明，自主神经系统可能在生理条件下的胰岛素分泌的控制中发挥作用。（内分泌学80：975，1967）
Adrenergic drugs (epinephrine, norepinephrine and isoproterenol) inhibit insulin secretion from pieces of rat pancreas incubated with glucose (150 mg/100 ml). This inhibitory effect appears to be mediated through alphareceptors for it is blocked by alpha- but little affected by beta-blocking agents. Cholinergic drugs (acetyl choline and carbamyl choline) have a stimulant effect using media containing glucose in low concentrations (100 mg/100 ml), and this effect is suppressed by simultaneous addition of atropine. These observations suggest that the autonomic nervous system may play a role in the control of insulin secretion under physiological conditions. (Endocrinology 80: 975, 1967)