The Measurement of Glomerular Filtration Rate and Effective Renal Plasma Flow in Man by Iothalamate 125I and Iodopyracet 131I
The Measurement of Glomerular Filtration Rate and Effective Renal Plasma Flow in Man by Iothalamate 125I and Iodopyracet 131I
复制标题
碘酞胺125I和吡拉西特131I测定人肾小球滤过率和有效肾血浆流量
DOI：
10.1161/01.cir.36.3.441
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发表时间：
1967
期刊：
影响因子：
37.8
通讯作者：
E. Sigman
中科院分区：
文献类型：
--
作者：
C. Elwood;E. Sigman
在21例患者中，90同时肾清除率菊粉和碘酞酸钠125碘，对氨基马尿酸（PAH）和碘吡拉西131碘测定通过恒定输注技术。用双道闪烁计数器同时测定了碘酞酸125 I和碘吡拉西131 I的放射性活度。菊粉和PAH的浓度通过标准化学技术测定。碘酞酸盐125 I与菊粉清除率的比值范围为0.93 - 1.09，平均值为1.00。碘吡拉西131 I与PAH清除率的比值范围为0.86 - 1.04，平均值为0.96。PAH和菊粉的化学测定需要大约8小时的技术人员时间，而放射性技术需要30分钟。碘酞酸盐125 I和碘吡拉西131 I的肾清除率测定是一种准确且省时的肾小球滤过率和有效肾血浆流量测量技术。
In 21 patients, 90 simultaneous renal clearances of inulin and sodium iothalamate 125I, and para-amino-hippuric acid (PAH) and iodopyracet 131I were determined by a constant infusion technique. The activities of iothalamate 125I and iodopyracet 131I were determined simultaneously in a dual-channel scintillation counter. The concentrations of inulin and PAH were determined by standard chemical techniques. The ratio of iothalamate 125I to inulin clearance ranged from 0.93 to 1.09 with a mean of 1.00. The ratio of iodopyracet 131I to PAH clearance varied from 0.86 to 1.04 with a mean of 0.96. The chemical determination of PAH and inulin required approximately 8 hours of technician time as compared with 30 minutes by the radioactive technique. The determination of the renal clearances of iothalamate 125I and iodopyracet 131I is an accurate and time-saving technique for the measurement of glomerular filtration rate and effective renal plasma flow.