Plant protein P3IP participates in the regulation of autophagy in Nicotiana benthamiana
Plant protein P3IP participates in the regulation of autophagy in Nicotiana benthamiana
复制标题
植物蛋白P3IP参与本塞姆氏烟草自噬的调控
DOI：
10.1080/15592324.2020.1861768
复制
发表时间：
2020-12-25
影响因子：
2.9
通讯作者：
Yan, Fei
中科院分区：
文献类型：
--
作者：
Jiang, Liangliang;Zheng, Xiying;Yan, Fei
自噬是一种广泛存在于真核生物中的降解机制，也参与了植物对病毒感染的应答。在我们前期的研究中，发现了一个新的宿主因子P3IP，它与水稻条纹病毒（rice stripe virus，RSV）p3相互作用，并介导其自噬降解，从而限制病毒的感染。本研究进一步发现本氏烟草P3IP（NbP3IP）参与了自噬的调控。过度表达NbP3IP诱导自噬，下调NbP3IP减少自噬。结合自噬介导的植物防御植物病毒和调节自噬的功能，我们认为P3IP参与了自噬的调节。
Autophagy, a bulk degradation system conserved among most eukaryotes, is also involved in responses to viral infection in plant. In our previous study, a new host factor P3IP was identified to interact with RSV (rice stripe virus) p3 and mediate its autophagic degradation to limit the viral infection. Here, we further discovered that P3IP of Nicotiana benthamiana (NbP3IP) participated in regulation of autophagy. Overexpression of NbP3IP induced autophagy and down-regulation of NbP3IP reduced autophagy. Combined the functions of autophagy-mediated plant defense against plant virus and regulation autophagy, we indicate that P3IP participates in the regulation of autophagy.