Cyclic Heptapeptides, Cordyheptapeptides C-E, from the Marine-Derived Fungus Acremonium persicinum SCSIO 115 and Their Cytotoxic Activities
Cyclic Heptapeptides, Cordyheptapeptides C-E, from the Marine-Derived Fungus Acremonium persicinum SCSIO 115 and Their Cytotoxic Activities
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DOI：
10.1021/np300152d
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发表时间：
2012-06-01
影响因子：
5.1
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
--
作者：
Chen, Ziming;Song, Yongxiang;Ju, Jianhua
从海洋真菌Acremonium persicinum SCSIO 115的发酵液中分离得到三个新的环七肽，即心七肽C-E（1-3）。基于广泛的MS以及1D和2D（COSY，HMQC和HMBC）NMR光谱数据分析，阐明了它们的平面结构。通过单晶X射线衍射、Marfey方法和手性相HPLC分析确定了氨基酸残基的绝对构型。化合物1和3显示出对SF-268、MCF-7和NCI-H460肿瘤细胞系的细胞毒性，IC 50值范围为2.5至12.1 μ M。
Three new cycloheptapeptides, cordyheptapeptides C-E (1-3), were isolated from the fermentation extract of the marine-derived fungus Acremonium persicinum SCSIO 115. Their planar structures were elucidated on the basis of extensive MS, as well as 1D and 2D (COSY, HMQC, and HMBC) NMR spectroscopic data analyses. The absolute configurations of the amino acid residues were determined by single-crystal X-ray diffraction, Marfey's method, and chiral-phase HPLC analysis. Compounds 1 and 3 displayed cytotoxicity against SF-268, MCF-7, and NCI-H460 tumor cell lines with IC50 values ranging from 2.5 to 12.1 mu M.