Street-Crossing Decision-Making: A Comparison between Patients with Age-Related Macular Degeneration and Normal Vision
Street-Crossing Decision-Making: A Comparison between Patients with Age-Related Macular Degeneration and Normal Vision
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DOI：
10.1167/iovs.12-10023
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发表时间：
2012-09-01
影响因子：
4.4
通讯作者：
Snyder, Benjamin D.
中科院分区：
文献类型：
--
作者：
Hassan, Shirin E.;Snyder, Benjamin D.
目的。我们确定了年龄相关性黄斑变性(AMD)受试者的过街决策是否与视力正常的青年和老年受试者一样准确和精确。方法：对13名AMD受试者和20名视力正常的年轻受试者和20名老年对照受试者在一条没有信号的街道上测量9个不同的间隔时间。在计算了所有间隙对的过街决策变量的可区分性(d‘)并将这些d’值输入一维尺度模型之后，估计了决策变量相对于“重心”的每个分布的平均值，并绘制了与间隙时间的关系图。得到的结果是一个非线性函数。以非线性函数的x截距(t(COG))与受试者测量的过街时间之差来计算每个受试者的过街决策精度。用非线性函数在t(COG)的斜率计算过街决策的精度。结果：所有受试者的过街决策都是准确的(P=0.55)。年龄对过街准确率的影响有显著差异(P=0.003)。与年龄较大的正常视力受试者(P=0.018)或老年性黄斑变性受试者(P=0.019)相比，年轻的正常视力受试者在过马路时做出的决定最不准确。AMD和年龄匹配的正常视力受试者之间的准确性没有显著差异(P=0.90)。结论：我们的数据表明，年龄和轻度中心视力丧失并不显著影响受试者在决定过马路时的准确性。年龄，但不是轻微的中央视力丧失，显著影响了受试者在做出过马路决定时的准确性。(投资眼科VS科学。2012年；53：6137-6144)doi：10.1167/iovs.12-10023
PURPOSE. We determined whether the street-crossing decisions of subjects with age-related macular degeneration (AMD) were as accurate and precise as those made by young and older subjects with normal vision.METHODS. Street-crossing decisions in 13 AMD subjects, and 20 young and 20 older control subjects with normal vision were measured along an un-signalized street for nine different gap times. After calculating the discriminability (d') of the street-crossing decision variable for all gap pairs and entering these d' values into a one-dimensional scaling model, the means of each distribution of the decision variable relative to a "center of gravity" were estimated and plotted against gap time. The resultant plot was a nonlinear function. Street-crossing decision accuracy was computed for each subject as the difference between the x-intercept of the nonlinear function (t(COG)) and subjects' measured street-crossing time. Street-crossing decision-making precision was computed as the value of the slope of the nonlinear function at t(COG).RESULTS. We found that all subjects were precise in their street-crossing decisions (P = 0.55). Significant differences in street-crossing accuracy were found as a function of age (P = 0.003). Compared to either the older normally-sighted (P = 0.018) or AMD (P = 0.019) subjects, the young normally-sighted subjects made the least accurate street-crossing decisions. No significant difference in accuracy was found between the AMD and age-matched normally-sighted subjects (P = 0.90).CONCLUSIONS. Our data suggested that age and mild central vision loss did not affect significantly a subject's precision in their street-crossing decisions. Age, but not mild central vision loss, significantly affected a subject's accuracy in their street-crossing decisions. (Invest Ophthalmol Vis Sci. 2012; 53: 6137-6144) DOI: 10.1167/iovs.12-10023