Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19.
Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19.
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DOI：
10.1016/j.xcrm.2021.100253
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发表时间：
2021-04-20
期刊：
影响因子：
--
通讯作者：
Sather DN
中科院分区：
文献类型：
--
作者：
Harrington WE;Trakhimets O;Andrade DV;Dambrauskas N;Raappana A;Jiang Y;Houck J;Selman W;Yang A;Vigdorovich V;Yeung W;Haglund M;Wallner J;Oldroyd A;Hardy S;Stewart SWA;Gervassi A;Van Voorhis W;Frenkel L;Sather DN
轻度严重急性呼吸综合征-冠状病毒-2（SARS-CoV-2）感染后保护性免疫的命运仍然不清楚。在这里，我们描述了一组从轻度SARS-CoV-2感染中恢复的参与者的抗体应答，随访6个月。我们测量免疫球蛋白A（伊加）、IgM和IgG与病毒抗原的结合和亲合力，并评估随时间推移的中和抗体应答。此外，我们将发热、性别、年龄和症状发作后的时间与抗体反应的影响相关联。我们观察到，总抗S三聚体，抗受体结合结构域（RBD），抗核衣壳蛋白（NP）IgG是相对稳定的6个月的后续行动，抗S和抗RBD的亲和力随着时间的推移而增加，发烧与较高水平的抗体。然而，中和抗体反应迅速衰减，并与IgM水平的下降密切相关。因此，尽管抗SARS-CoV-2的总抗体可能持续存在，但功能性抗体，特别是IgM，迅速丧失。这些观察结果对轻度SARS-CoV-2感染后保护性免疫的持续时间有影响。在轻度COVID-19后，抗S-三聚体、RBD和NP IgG稳定长达6个月。随着时间的推移，对病毒的中和活性迅速衰减。中和与抗S-三聚体IgM滴度最密切相关。发烧患者的抗体最初较高，但达到相似的最低点哈灵顿等人，报告称，在患有轻度COVID-19的成年人中，IgG反应可维持>6个月，并与发热相关。中和活性迅速衰减，与抗S-三聚体IgM滴度的损失相关。因此，中和抗体在轻度COVID-19感染后迅速消退，尽管IgG长期维持。
The fate of protective immunity following mild severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection remains ill defined. Here, we characterize antibody responses in a cohort of participants recovered from mild SARS-CoV-2 infection with follow-up to 6 months. We measure immunoglobulin A (IgA), IgM, and IgG binding and avidity to viral antigens and assess neutralizing antibody responses over time. Furthermore, we correlate the effect of fever, gender, age, and time since symptom onset with antibody responses. We observe that total anti-S trimer, anti-receptor-binding domain (RBD), and anti-nucleocapsid protein (NP) IgG are relatively stable over 6 months of follow-up, that anti-S and anti-RBD avidity increases over time, and that fever is associated with higher levels of antibodies. However, neutralizing antibody responses rapidly decay and are strongly associated with declines in IgM levels. Thus, while total antibody against SARS-CoV-2 may persist, functional antibody, particularly IgM, is rapidly lost. These observations have implications for the duration of protective immunity following mild SARS-CoV-2 infection. After mild COVID-19, anti-S-trimer, RBD, and NP IgG are stable for up to 6 months Neutralization activity against the virus rapidly decays over time Neutralization is most strongly correlated with anti-S-trimer IgM titers Antibodies are initially higher in those with fever but reach similar nadirs Harrington et al., report that in adults with mild COVID-19, IgG responses are maintained for >6 months and are correlated with fever. Neutralization activity rapidly decays, correlating with the loss of anti-S-trimer IgM titers. Thus, neutralizing antibodies fade quickly after mild COVID-19 infection, despite the long-term maintenance of IgG.
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DOI：
10.1093/infdis/jiaa784
发表时间：
2021-03-29
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Klingler J;Weiss S;Itri V;Liu X;Oguntuyo KY;Stevens C;Ikegame S;Hung CT;Enyindah-Asonye G;Amanat F;Baine I;Arinsburg S;Bandres JC;Kojic EM;Stoever J;Jurczyszak D;Bermudez-Gonzalez M;Nádas A;Liu S;Lee B;Zolla-Pazner S;Hioe CE
通讯作者：
Hioe CE
影响因子：
64.8
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Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
DOI：
10.1016/s0140-6736(20)32009-2
发表时间：
2020-10-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Anand S;Montez-Rath M;Han J;Bozeman J;Kerschmann R;Beyer P;Parsonnet J;Chertow GM
通讯作者：
Chertow GM
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel