Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4.
Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4.
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DOI：
10.1097/meg.0b013e3283140eea
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发表时间：
2009-06
影响因子：
2.1
通讯作者：
O'Sullivan M
中科院分区：
文献类型：
--
作者：
Murphy G;Thornton J;McManus R;Swan N;Ryan B;Hughes DJ;O'Morain CA;O'Sullivan M
越来越多的证据表明，幽门螺杆菌（H。pylori）诱导的炎症，影响发展为非贲门胃癌的易感性。本研究旨在研究一系列炎症基因中的单核苷酸多态性（SNP）是否与胃癌发展之前最常见的病理学即H.幽门相关性胃炎和肠上皮化生。共对250例患者进行了IL-1B、IL-1 RN、TNF、TLR 4和IL-10基因中11个SNP的基因分型。研究人群包括H。pylori未感染（“正常”）对照组（n=96），H. pylori阳性胃炎91例，肠上皮化生63例。使用Taqman等位基因鉴别测定进行基因分型。根据潜在的混杂因素调整了胃病组的比值比。在患者组间研究的任何“风险”等位基因的携带频率或纯合性方面没有发现差异。没有证据表明IL-1B、IL-1 RN、TNF、TLR 4和IL-10基因或检测的单倍型中的SNP与慢性胃炎或肠上皮化生风险增加相关。这项研究没有发现与慢性胃炎或肠上皮化生风险增加相关的证据。
Increasing evidence suggests that polymorphisms in key mediator genes of Helicobacter pylori (H. pylori) -induced inflammation, influence susceptibility to developing non-cardia gastric cancer. This study aimed to investigate if single nucleotide polymorphisns (SNPs) in a series of inflammatory genes were associated with the development of the most common pathologies thought to precede gastric cancer development namely; H. pylori associated gastritis and intestinal metaplasia. A total of 250 patients were genotyped for 11 SNPs in the IL-1B, IL-1RN, TNF, TLR4 and IL-10 genes. The study population comprised H. pylori uninfected (‘normal’) control patients (n=96), H. pylori positive gastritis (n=91) and intestinal metaplasia patients (n=63). Genotyping was performed using Taqman allelic discrimination assays. Odds ratios for gastric disease groups were adjusted for potential confounding factors. No differences were identified in frequency of carriage, or homozygosity, for any of the ‘risk’ alleles investigated across the patient groups. There was no evidence to suggest an association with increased risk of developing either chronic gastritis or intestinal metaplasia with SNPs in the IL-1B, IL-1RN, TNF, TLR4 and IL-10 genes.or haplotypes tested. This study found no evidence of an association with increased risk of developing either chronic gastritis or intestinal metaplasia with the SNPs or haplotypes tested.