Examining differences in psychological adjustment problems among children conceived by assisted reproductive technologies
Examining differences in psychological adjustment problems among children conceived by assisted reproductive technologies
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DOI：
10.1177/0165025409338444
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发表时间：
2009-09-01
影响因子：
3.7
通讯作者：
Thapar, Anita
中科院分区：
文献类型：
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作者：
Shelton, Katherine H.;Boivin, Jacky;Thapar, Anita
本研究的目的是研究通过使用父母的配子（同源）、精子捐赠、卵子捐赠、胚胎捐赠和代孕的辅助生殖技术受孕的儿童的心理调节水平是否存在差异。父母提供了769名5至9岁儿童的心理功能信息，这些儿童出生时使用抗逆转录病毒治疗（来自所描述的五组）。在不同的受孕组之间进行了比较，与英国国家标准进行了比较，对于多胞胎的子样本，与年龄匹配的双胞胎样本进行了比较。除了卵子捐赠组的父亲对孩子行为问题的评价高于其他ART组外，受孕组之间没有发现任何差异。ART治疗类型（ICSI与IVF、GIFT和IUI）未观察到任何影响。有一些证据表明，与国家标准相比，通过同种体外受精受孕的儿童的行为问题和亲社会行为较低。然而，总的来说，各组之间以及与自然受孕的孩子相比，在母亲或父亲评估的适应问题上的一致差异并不明显。通过辅助生殖技术孕育的孩子，无论他们是否与父母有遗传关系或无关，或通过代孕出生，他们的心理适应水平没有差异。与自然受孕的孩子相比，他们在童年中期出现心理适应问题的风险也并不大。
The aim of this study was to examine whether there was variation in levels of psychological adjustment among children conceived through Assisted Reproductive Technologies using the parents' gametes (homologous), sperm donation, egg donation, embryo donation and surrogacy. Information was provided by parents about the psychological functioning of 769 children aged 5 to 9 years who had been born using ART (from the five groups described). Comparisons were made between the different conception groups, to UK national norms and, for a sub-sample of multiple births, to an age-matched twin sample. No differences were found between the conception groups except that fathers from the egg donation group rated children higher in conduct problems compared to other ART groups. No effects were observed by ART treatment type (ICSI vs. IVF, GIFT and IUI). There was some evidence of lower conduct problems and prosocial behaviour among children conceived through homologous IVF compared to national norms. Taken together, however, consistent differences between groups and in comparison to naturally conceived children were not apparent for mother- or father-rated adjustment problems. Children conceived with assisted reproductive technologies, regardless of whether they are genetically related or unrelated to their parents or born by gestational surrogacy do not differ in their levels of psychological adjustment. Nor do they appear to be at greater risk of psychological adjustment problems in middle childhood compared to naturally conceived children.