Measuring tongue volumes and visualizing the chewing and swallowing process using real-time TrueFISP imaging - initial clinical experience in healthy volunteers and patients with acromegaly
Measuring tongue volumes and visualizing the chewing and swallowing process using real-time TrueFISP imaging - initial clinical experience in healthy volunteers and patients with acromegaly
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DOI：
10.1007/s00330-004-2596-6
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发表时间：
2005-05-01
影响因子：
5.9
通讯作者：
Ruehm, SG
中科院分区：
文献类型：
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作者：
Ajaj, W;Goyen, M;Ruehm, SG
这项研究评估了用于定量舌体体积的二维(2D)TrueFISP成像和用于评估健康志愿者和肢端肥大症患者的咀嚼和吞咽情况的实时TrueFISP成像。在50名健康志愿者中，使用2D TrueFisp序列测量了舌体体积。咀嚼和吞咽使用实时TrueFISP序列进行可视化。10名肢端肥大症患者接受了两次同样的磁共振成像检查：一次是在治疗前，另一次是在治疗6个月后。在治疗前，健康志愿者的平均舌量男性为140毫升，女性为90毫升，肢端肥大症患者的平均舌量为男性180毫升，女性145毫升。然而，治疗6个月后，肢端肥大症患者的平均舌量已减少到男性的154毫升和女性的125毫升。所有志愿者的咀嚼和吞咽过程都是正常的。治疗前，只有两名患者表现出咀嚼和吞咽病理，治疗后症状消失。肢端肥大症患者的舌体体积比健康志愿者大，TrueFISP成像被证明可以实时显示咀嚼和吞咽，并能够检测可能的病理。此外，TrueFISP成像可用于监测肢端肥大症患者的治疗方法。
This study assessed both two-dimensional (2D) TrueFISP imaging for quantifying tongue volume and real-time TrueFISP imaging for evaluating chewing and swallowing in healthy volunteers and patients with acromegaly. In 50 healthy volunteers, tongue volumes were measured using a 2D TrueFISP sequence. Chewing and swallowing were visualized using a real-time TrueFISP sequence. Ten patients with acromegaly were examined twice with the same magnetic resonance imaging protocol: once prior to therapy and a second time 6 months after therapy. Prior to therapy, healthy volunteers had an average tongue volume of 140 ml for men and 90 ml for women, and patients with acromegaly had an average tongue volume of 180 ml for men and 145 ml for women. However, 6 months after therapy the mean tongue volumes in patients with acromegaly had decreased to 154 ml in the men and to 125 ml in the women. The chewing and swallowing process was normal in all volunteers. Prior to therapy, just two patients showed a chewing and swallowing pathology, which disappeared after therapy. Patients with acromegaly had larger tongue volumes than healthy volunteers, and TrueFISP imaging proved feasible for visualizing chewing and swallowing in real time and is capable of detecting possible pathologies. Furthermore, TrueFISP imaging can be used to monitor therapeutic approaches in patients with acromegaly.