Synthesis of NG, NG Dimethylarginine by Human Endothelial Cells
Synthesis of NG, NG Dimethylarginine by Human Endothelial Cells
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人内皮细胞合成 NG、NG 二甲基精氨酸
DOI：
10.3109/10623329309102688
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发表时间：
1993
影响因子：
--
通讯作者：
G. Whitley
中科院分区：
文献类型：
--
作者：
S. Fickling;A. Leone;S. Nussey;P. Vallance;G. Whitley
内皮细胞从 L-精氨酸合成一氧化氮，该过程可以被血浆和尿液的成分 NG、NG 二甲基精氨酸（不对称二甲基精氨酸；ADMA）抑制。在本研究中，人脐静脉内皮细胞培养物已被证明可以释放 ADMA。 7 天以上 5.1 ± 2.8； μg ADMA 由 107 个细胞产生（n = 8）。这些结果表明存在可能调节内皮内一氧化氮合成的代谢途径。
Endothelial cells synthesise nitric oxide from L-arginine and this process can be inhibited by NG, NG dimethylarginine (asymmetric dimethylarginine; ADMA), a constituent of plasma and urine. In the present study cultures of human umbilical vein endothelial cells have been shown to release ADMA. Over 7 days 5.1 ± 2.8; μg ADMA was produced by 107 cells (n = 8). These results suggest the presence of a metabolic pathway that may regulate NO synthesis within the endothelium.