Pathophysiology and Animal Models of Cancer-Related Painful Peripheral Neuropathy
Pathophysiology and Animal Models of Cancer-Related Painful Peripheral Neuropathy
复制标题
DOI：
10.1634/theoncologist.2009-s503
复制
发表时间：
2010-05-01
期刊：
影响因子：
5.8
通讯作者：
Bennett, Gary J.
中科院分区：
文献类型：
--
作者：
Bennett, Gary J.
毫无疑问，癌症患者疼痛性周围神经病变有几个原因。一些机制直接归因于肿瘤;其他机制与治疗有关，无论是手术，放射治疗还是化疗。已经开发了几种动物模型来研究导致神经病理性疼痛的病理生理机制。这些包括基于炎症的模型、神经创伤诱导的模型和化学疗法诱导的神经性疼痛模型。我和我的同事最近发现了外周感觉纤维中线粒体结构和功能的异常，这些异常与常见化疗药物诱导的神经性疼痛有关，并且可以通过增强线粒体功能的药物来逆转。我们希望，进一步识别和阐明涉及外周的病理生理机制将有助于我们开发新的药物和治疗方案。肿瘤学家2010; 15（增刊2）：9-12
There are undoubtedly several causes of painful peripheral neuropathy in cancer patients. Some mechanisms are directly attributable to the tumor; others lie with the therapy, be it surgery, radiation, or chemotherapy. Several animal models have been developed to study the pathophysiological mechanisms that contribute to neuropathic pain. These include inflammation-based models, nerve trauma-induced models, and chemotherapy-induced models of neuropathic pain. My colleagues and I recently identified abnormalities in mitochondrial structure and function in peripheral sensory fibers that are associated with neuropathic pain induced by common chemotherapeutic agents and that can be reversed by agents that enhance mitochondrial function. Our hope is that further identification and clarification of the pathophysiological mechanisms involved at the periphery will help us to develop new classes of medicines and treatment options. The Oncologist 2010; 15(suppl 2): 9-12