2,3-Functionalization of furans, benzofurans and thiophenes via magnesiation and sulfoxide-magnesium exchange
2,3-Functionalization of furans, benzofurans and thiophenes via magnesiation and sulfoxide-magnesium exchange
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DOI：
10.1039/b907330b
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Knochel, Paul
中科院分区：
文献类型：
--
作者：
Melzig, Laurin;Rauhut, Christian B.;Knochel, Paul
TMPMgCl中心点LiCl和iPrMgCl中心点LiCl的使用允许各种2-芳基亚砜基呋喃、噻吩和苯并呋喃的顺序2,3双官能化。随后使用相同的试剂允许呋喃和噻吩支架的所有4个位置的选择性全功能化。
The use of TMPMgCl center dot LiCl and iPrMgCl center dot LiCl allows a sequential 2,3-difunctionalization of various 2-arylsulfinyl furans, thiophenes and benzofurans. Subsequent use of the same reagents permits a selective full functionalization of all 4 positions of the furan and thiophene scaffolds.