Clinical Implications of Understanding Radiographic Findings in Relation to Clinical Outcomes in Rheumatoid Arthritis
Clinical Implications of Understanding Radiographic Findings in Relation to Clinical Outcomes in Rheumatoid Arthritis
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DOI：
10.3899/jrheum.090125
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发表时间：
2009-06-01
影响因子：
3.9
通讯作者：
Keystone, Edward C.
中科院分区：
文献类型：
--
作者：
Keystone, Edward C.
类风湿性关节炎（RA）的临床进展和对治疗的长期反应通常通过量化关节间隙狭窄和系列平片上可见的侵蚀的变化来评估。在接受经典疾病缓解抗风湿药物治疗的患者中，影像学上所见的关节损伤通常与长期功能障碍直接相关。然而，这种关系在接受生物制剂治疗的患者中并不明确。在评估治疗效果时，需要考虑到接受生物疗法治疗的RA患者的临床和影像学结局之间的明显分离。（J RheLlinatol 2009;36 Suppl 82：11-16; doi：10.3899/jrheum.090125）
The clinical progression of rheumatoid arthritis (RA) and longterm response to therapy is generally assessed by quantifying changes in joint space narrowing and erosions visible on serial plain radiographs. In patients treated with classic disease modifying antirheumatic drugs, the joint damage seen on radiographic images is usually directly associated with longterm functional disability. However, this relationship is not its clearly defined in patients treated with biologic agents. The apparent dissociation between clinical and radiologic outcomes in patients with RA who are treated with biologic therapies needs to be taken into consideration when evaluating the efficacy of treatment. (J RheLlinatol 2009;36 Suppl 82: 11-16; doi:10.3899/jrheum.090125)