Docosahexaenoic Acid and Amino Acid Contents in Pasteurized Donor Milk are Low for Preterm Infants.
Docosahexaenoic Acid and Amino Acid Contents in Pasteurized Donor Milk are Low for Preterm Infants.
复制标题
对于早产儿来说，巴氏灭菌供乳中的二十二碳六烯酸和氨基酸含量较低。
DOI：
10.1016/j.jpeds.2010.06.017
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Rogers,LynetteK
中科院分区：
文献类型：
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作者：
Valentine,ChristinaJ;Morrow,Georgia;Fernandez,Soledad;Gulati,Parul;Bartholomew,Dennis;Long,Don;Welty,StephenE;Morrow,ArdytheL;Rogers,LynetteK
目的评价巴氏消毒供体母乳在游离脂肪酸和氨基酸含量方面是否能满足早产儿的营养需求。研究设计前瞻性地从俄亥俄州母乳银行的39名捐赠者那里收集了母乳样本。在巴氏消毒前后测量供体奶样品中的脂肪酸和氨基酸组成，并将其与先前发表的研究结果和早产儿营养指南进行比较。早产儿供体奶的营养充分性是基于估计每日摄入量为150毫升/公斤。统计显著性进行了调整，以解释多重比较。结果巴氏灭菌对供乳成分无明显影响。供体牛奶中的二十二碳六烯酸水平（0.1 mol wt %）以及甘氨酸、天冬氨酸、缬氨酸、苯丙氨酸、脯氨酸、赖氨酸、精氨酸、丝氨酸和组氨酸的浓度均显著低于先前报道的牛奶浓度。结论供体奶经巴氏灭菌后无明显影响，但其二十二碳六烯酸和氨基酸浓度较低。有针对性的营养补充的人供体母乳喂养早产儿可能是必要的。
OBJECTIVETo evaluate whether pasteurized donor human milk meets the nutritional needs of preterm infants in terms of free fatty acid and amino acid contents.STUDY DESIGNMilk samples were prospectively collected from 39 donors to the Mothers' Milk Bank of Ohio. The fatty acid and amino acid compositions in donor milk samples were measured before and after pasteurization, and values were compared with previously published findings and preterm infant nutrition guidelines. The nutritional adequacy of donor milk for preterm infants was based on estimated daily intake of 150 mL/kg. Statistical significance was adjusted to account for multiple comparisons.RESULTSPasteurization did not appreciably affect donor milk composition. Docosahexaenoic acid level (0.1 mol wt %), and concentrations of glycine, aspartate, valine, phenylalanine, proline, lysine, arginine, serine, and histidine in donor milk were all significantly lower than previously reported concentrations in milk.CONCLUSIONSDonor milk is not substantially affected by pasteurization, but has low concentrations of docosahexaenoic acid and amino acids. Targeted nutritional supplementation of human donor milk for feeding preterm infants might be warranted.