Development of luteinizing hormone releasing hormone neurones.
Development of luteinizing hormone releasing hormone neurones.
复制标题
黄体生成素释放激素神经元的发育。
DOI：
10.1046/j.1365-2826.2001.00609.x
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发表时间：
2001
影响因子：
3.2
通讯作者：
Wray,S
中科院分区：
文献类型：
--
作者：
Wray,S
本文就神经内分泌促黄体生成素释放激素（LHRH）细胞的研究进展进行综述。神经内分泌LHRH细胞起源于中枢神经系统外的鼻位，然后在产前发育期间迁移到前脑。正是这些LHRH细胞群负责生殖功能，在出生后成为下丘脑-垂体-性腺轴的组成部分。这一系统发育的中断会导致生殖功能障碍。增加我们对LHRH神经内分泌细胞的了解，为我们更精确地研究控制生殖发育的机制，包括激活和失败，创造了条件。此外，操纵LHRH系统的分子和细胞生物学的能力为理解关键的神经生物学问题开辟了途径，如表型承诺、轴突路径寻找和神经元迁移机制。每个主题依次进行讨论，并指出控制神经内分泌LHRH系统发展的潜在机制。
This review concentrates on some of the recent discoveries and future questions relevant to the development of the neuroendocrine luteinizing hormone releasing hormone (LHRH) cells. Neuroendocrine LHRH cells originate outside the central nervous system, in the nasal placode, and thereafter migrate into the forebrain during prenatal development. It is this population of LHRH cells that is responsible for reproductive function, becoming integral members of the hypothalamo‐pituitary‐gonadal axis postnatally. Disruption of the development of this system results in reproductive dysfunction. Increasing our understanding of LHRH neuroendocrine cells establishes conditions where we can look with greater precision at the mechanisms controlling reproductive development, both activation and failure. In addition, the ability to manipulate the molecular and cellular biology of the LHRH system opens the route to understanding critical neurobiological issues such as phenotypic commitment, axonal path finding and mechanisms involved in neuronal migration. Each of the topics is discussed in turn and potential mechanisms controlling the development of the neuroendocrine LHRH system are indicated.