Low-molecular-weight GTP-binding proteins and leukocyte signal transduction.
Low-molecular-weight GTP-binding proteins and leukocyte signal transduction.
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低分子量 GTP 结合蛋白和白细胞信号转导。
DOI：
10.1002/jlb.58.3.263
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发表时间：
1995
影响因子：
5.5
通讯作者：
Quinn,MT
中科院分区：
文献类型：
--
作者：
Quinn,MT
白细胞信号转导通路的研究进展表明，许多信号转导通路是由低分子量GTP结合蛋白（LMWGs）调节的。LMWG是一个不断增长的GTP结合蛋白家族的成员，称为Ras超家族，并作为分子开关，用于调节几乎所有细胞中的广泛信号转导途径。在白细胞中，已显示LMWG参与基本细胞功能，如生长控制、分化、细胞骨架组织、细胞因子和趋化因子诱导的信号传导事件、烟酰胺腺嘌呤二核苷酸磷酸氧化酶活性降低、磷脂代谢和胞内囊泡转运和分泌，随着我们对调节白细胞信号转导的调节途径的进一步了解，这些功能中的更多功能肯定会被鉴定出来。这篇综述将总结我们目前对这一快速发展的研究领域的理解。
Recent progress on the understanding of leukocyte signal transduction pathways indicates that many of these pathways are modulated by low-molecular-weight GTP-binding proteins (LMWGs). LMWGs are members of a growing family of GTP-binding proteins known as the Ras superfamily and act as molecular switches for regulating a wide range of signal-transduction pathways in virtually all cells. In leukocytes, LMWGs have been shown to participate in essential cellular functions such as growth control, differentiation, cytoskeletal organization, cytokine and chemoattractant-induced signaling events, reduced nicotinamide adenine dinucleotide phosphate oxidase activity, phospholipid metabolism, and intracellular vesicle transport and secretion, and many more of these functions will certainly be identified as we gain a further understanding of regulatory pathways modulating leukocyte signal transduction. This review will summarize our current understanding of this rapidly advancing area of research.