A model of deep experimental hypothermia and rewarming in rat
A model of deep experimental hypothermia and rewarming in rat
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DOI：
10.1016/j.jtherbio.2004.04.001
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发表时间：
2004-05-01
影响因子：
2.7
通讯作者：
Palomeque, J
中科院分区：
文献类型：
--
作者：
Alva, N;Carbonell, T;Palomeque, J
我们研究了深低温和复温对大鼠肝脏局部血流量、酸碱平衡和血浆转氨酶水平的影响。当复温温度为0.35℃/min时，死亡率较高。在0.25℃/min的降温速率下，所有动物均存活下来，低温所致的门静脉血流量减少得以恢复。根据乳酸水平，血流量减少并不影响有氧代谢。在该动物模型中，通过遵循α-STAT策略控制通气量来维持pH。表明深低温方案可以安全地用于低温受试者的复温。(C)2004爱思唯尔有限公司。保留所有权利。
We studied the effects of deep hypothermia and rewarming on hepatic regional blood flow, acid-base balance and level of plasma transaminases in rat. A high mortality was found when rewarming at 0.35degreesC/min. At a rate of 0.25degreesC/min, all animals survived and the decrease in portal vein flow induced by hypothermia was restored. The reduced blood flow did not affect aerobic metabolism based on lactate levels. In this animal model, pH was maintained by controlling ventilation following the alpha-stat strategy. It appears that deep hypothermia protocol could be safely used to rewarm hypothermic subjects. (C) 2004 Elsevier Ltd. All rights reserved.