Distribution of the serotonin 2C (5HT2C) receptor gene -759C/T polymorphism in patients with schizophrenia and normal controls.
Distribution of the serotonin 2C (5HT2C) receptor gene -759C/T polymorphism in patients with schizophrenia and normal controls.
复制标题
精神分裂症患者和正常对照中血清素2C（5HT2C）受体基因-759C/T多态性的分布。
DOI：
10.1097/01.ypg.0000107930.32051.8e
复制
发表时间：
2004
影响因子：
0.9
通讯作者：
Perry,PaulJ
中科院分区：
文献类型：
--
作者：
Ellingrod,VickiL;Miller,Del;Ringold,JohnC;Perry,PaulJ
BackgroundIn patients with schizophrenia, the percentage of patients with diabetes has been found to be twice that of the normal population. The risk factors for this higher rate are unknown, although dietary, lifestyle, and genetic factors have all been suggested. Recently, a polymorphism (–759C/T) in the serotonin 2C (5HT2C) receptor promoter region has been associated with the development of diabetes in a normal control population, with the frequency of the T allele being higher in subjects without diabetes.AimTo determine whether the distribution of the–759C/T polymorphism of the 5HT2C receptor is different among patients with schizophrenia and normal controls.MethodsDNA from 100 patients with schizophrenia and 81 normal controls were analyzed for the 5HT2C receptor–759C/T polymorphism to determine its allelic frequencies in these two groups.ResultsUsing a chi-squared analysis, no statistical differences in the distribution of C alleles and T alleles were found between the two groups (P= 0.2931).ConclusionsPatients with schizophrenia have a higher risk for developing diabetes than the general population. We did not find a higher distribution of the–759 T allele of the 5HT2C receptor in normal controls compared with in patients with schizophrenia. This suggests the higher prevalence of diabetes in schizophrenia is not due to this polymorphism.
