Baboon/human homologies examined by spectral karyotyping (SKY): a visual comparison
Baboon/human homologies examined by spectral karyotyping (SKY): a visual comparison
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DOI：
10.1159/000015070
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Moore, CM
中科院分区：
文献类型：
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作者：
Best, RG;Diamond, D;Moore, CM
利用光谱核型技术（SKY）分析了狒狒（Papio hamadryas）中期染色体，这是一种结合荧光显微镜、ccd成像和傅立叶光谱的技术。使用人类染色体探针对狒狒中期进行的SKY分析比较结果与两个物种之间的大多数比较基因定位数据一致。这些数据也与早期比较猕猴和人类染色体的研究相一致。人类（HSA）的2号染色体与狒狒（PHA）的12号染色体（HSA 2q）和13号染色体（HSA 2p）同源，而狒狒的3条染色体对应于人类的两条染色体：PHA 3与HSA 7和HSA 21， PHA 7与HSA 14和HSA 15， PHA 10与HSA 20和HSA 22。这些结果支持了人科和蠓科基因组之间的一致性。
Baboon (Papio hamadryas) metaphase chromosomes were analyzed using spectral karyotyping (SKY), a technique combining fluorescence microscopy, CCD-imaging, and Fourier spectroscopy. Results from a comparison of SKY analyses using probes derived from human chromosomes on baboon metaphases were consistent with the majority of comparative gene mapping data between the two species. These data were also compatible with earlier studies comparing macaque and human chromosomes. Human (HSA) chromosome 2 was homologous to baboon (PHA) chromosomes 12 (HSA 2q) and 13 (HSA 2p), whereas three baboon chromosomes corresponded to two different human chromosomes: PHA 3 to HSA 7 and HSA 21, PHA 7 to HSA 14 and HSA 15, and PHA 10 to HSA 20 and HSA 22. These results support the retained synteny between the Hominidae and Cercopithecidae genomes.