Combination Atmospheric Pressure Solids Analysis Probe and Desorption Electrospray Ionization Mass Spectrometry Ion Source
Combination Atmospheric Pressure Solids Analysis Probe and Desorption Electrospray Ionization Mass Spectrometry Ion Source
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DOI：
10.1021/ac901324j
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发表时间：
2009-11-01
影响因子：
7.4
通讯作者：
McEwen, Charles N.
中科院分区：
文献类型：
--
作者：
Lloyd, Julie A.;Harron, Andrew F.;McEwen, Charles N.
大气固体探针分析（ASAP）探头进行解吸电喷雾离子化（DESI）使用市售的离子源作为一种手段进行了研究。将固体和液体样品以及原始尿液样品放置在单独的熔点管上，并插入加热的气流中进行ASAP分析，或插入带电的溶剂喷雾中进行类似的实验。样品的极性、挥发性、质量（100-17 000 Da）和浓度（纯至亚微摩尔）不等。在短时间尺度上的单次采集内获得多个样品的质谱（
The atmospheric solids probe analysis (ASAP) probe was investigated as a means for conducting desorption electrospray ionization (DESI) using a commercially available ion source. Solid and liquid samples as well as a raw urine sample were placed on individual melting point tubes and were inserted into either a heated gas stream for ASAP analysis or a charged solvent spray for DESI-like experiments. Samples ranged in polarity, volatility, mass, (100-17 000 Da), and concentration (neat to submicro-molar). Mass spectra of multiple samples were obtained within a single acquisition on a short time scale (