Replication Timing Becomes Intertwined with 3D Genome Organization.
Replication Timing Becomes Intertwined with 3D Genome Organization.
复制标题
复制时间与 3D 基因组组织交织在一起。
DOI：
10.1016/j.cell.2019.01.027
复制
发表时间：
2019
期刊：
影响因子：
64.5
通讯作者：
Duan,Zhijun
中科院分区：
文献类型：
--
作者：
Ma,Jian;Duan,Zhijun
通过剖析空间基因组组织与DNA复制时机之间的联系，Sima等人。（2018）发现早期复制控制元件（ERCEs），这是一种新型的顺式作用元件，可调节复制时间，转录和基因组组织的多层三维特征。这项研究对于解开高阶基因组结构和功能的控制元件具有重要意义。
Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type ofcis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.