Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats.
Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats.
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DOI：
10.4137/cmc.s18759
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Sugimachi M
中科院分区：
文献类型：
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作者：
Kawada T;Li M;Sata Y;Zheng C;Turner MJ;Shimizu S;Sugimachi M
压力反射平衡图描述了输入压力与交感神经活动（SNA）和动脉压（AP）之间的关系。为校正压力感受性反射平衡图的SNA轴（横坐标），在正常对照大鼠（NC，n = 9）和慢性心力衰竭大鼠（CHF，n = 6）中，观察了静脉推注苯肾上腺素（0.2-50 μg/kg）或去甲肾上腺素（NE，0.02-5 μg/kg）的AP反应。CHF组剂量-效应曲线的最大斜率显著小于NC组（苯肾上腺素57.3 ± 5.2 vs 80.9 ± 6.3 mmHg/decade，NE 60.2 ± 7.8 vs 80.4 ± 5.9 mmHg/decade; P < 0.01）。最大斜率的CHF/NC比率用于校准SNA。虽然校准的压力反射平衡图显示增加的最大SNA和工作点SNA在CHF大鼠与NC大鼠相比，增加的幅度小于预期的过量血浆NE浓度在CHF大鼠。CHF组血浆NE浓度可能高于SNA。
A baroreflex equilibrium diagram describes the relation between input pressure and sympathetic nerve activity (SNA) and that between SNA and arterial pressure (AP). To calibrate the SNA axis (abscissa) of the baroreflex equilibrium diagram, the AP response to intravenous bolus injections of phenylephrine (0.2–50 μg/kg) or norepinephrine (NE, 0.02–5 μg/kg) was examined in normal control rats (NC, n = 9) and rats with chronic heart failure (CHF, n = 6). The maximum slope of the dose–effect curve was significantly smaller in the CHF group than in the NC group (57.3 ± 5.2 vs 80.9 ± 6.3 mmHg/decade for phenylephrine, 60.2 ± 7.8 vs 80.4 ± 5.9 mmHg/decade for NE; P < 0.01). The CHF/NC ratio of the maximum slope was used to calibrate SNA. While the calibrated baroreflex equilibrium diagram showed increased maximum SNA and operating-point SNA in CHF rats compared with NC rats, the magnitude of increase was smaller than that expected from the excess plasma NE concentration in CHF rats. Plasma NE concentration in the CHF group could be disproportionally high relative to SNA.