Multiparameter flow cytometry quantification of bone marrow plasma cells at diagnosis provides more prognostic information than morphological assessment in myeloma patients
Multiparameter flow cytometry quantification of bone marrow plasma cells at diagnosis provides more prognostic information than morphological assessment in myeloma patients
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DOI：
10.3324/haematol.2009.009100
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发表时间：
2009-11-01
期刊：
影响因子：
--
通讯作者：
San Miguel, Jesus F.
中科院分区：
文献类型：
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作者：
Paiva, Bruno;Vidriales, Maria-Belen;San Miguel, Jesus F.
在多发性骨髓瘤患者中，用常规的形态学方法定量检测骨髓浆细胞的预后价值有限，而多参数流式细胞术免疫表型的优点仍被认为是未经证实的。在这里，我们比较了形态学和多参数弓形细胞术获得的骨髓浆细胞计数，并在765名新诊断的、统一治疗的多发性骨髓瘤患者中探索了这两种技术对预后的潜在影响。尽管多参数流式细胞术通常产生较低的浆细胞计数(中位数百分比分别为11%和40%；p
Quantification of bone marrow plasma cells in multiple myeloma patients using conventional morphology is of limited prognostic value, while the merit of multiparameter flow cytometry immunophenotyping is still considered unproven. Here we compare the bone marrow plasma cell counts obtained by morphology and multiparameter Bow cytometry and explore the potential prognostic impact of both techniques in 765 newly diagnosed, uniformly treated multiple myeloma patients. Although multiparameter flow cytometry generally yields lower plasma cell counts (median percentage of 11% vs. 40%, respectively; p