EXERCISE-INDUCED CHANGES IN OXYGEN-SATURATION IN THE CALF MUSCLES OF ELDERLY SUBJECTS WITH PERIPHERAL VASCULAR-DISEASE
EXERCISE-INDUCED CHANGES IN OXYGEN-SATURATION IN THE CALF MUSCLES OF ELDERLY SUBJECTS WITH PERIPHERAL VASCULAR-DISEASE
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DOI：
10.1093/geronj/49.3.b128
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发表时间：
1994-05-01
期刊：
影响因子：
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通讯作者：
POSNER, JD
中科院分区：
文献类型：
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作者：
MCCULLY, KK;HALBER, C;POSNER, JD
本研究无创测量了年轻（n = 6，28 +/- 6岁）、老年健康（n = 20，68 +/- 7岁）和患有轻度外周血管疾病（PVD）的老年受试者（n = 8，72 +/- 4岁）的血红蛋白氧饱和度。使用近红外光谱法（NIRS）测量血红蛋白氧饱和度作为在760和850 nm光下的吸收的差异。研究了轻度跖屈运动后比目鱼肌外侧肌的变化。氧饱和度恢复的时间常数（HBO 2 Tc）在年轻健康受试者中为21.5 +/-8.6s，在老年健康受试者中为26.9 +/-13.5s。PVD受试者的HbO（2）Tc值在“坏"腿为104.4 +/- 41.1 s，在”好"腿为57.6 +/- 42.2 s。HbO（2）Tc与踝臂压力之间的相关性显著（r（2）= 0.63，p <0.001）。6名年轻的正常人，5名老年正常人和7名PVD受试者也进行了渐进式步行试验。正常受试者完成测试没有困难，和老年正常受试者表现出进行性脱氧。PVD受试者抱怨小腿疼痛（5人中有4人能够完成），并在整个测试过程中显示出接近最大的脱氧。总之，NIRS测量显示出作为评价氧饱和度动力学的方法的前景，特别是在轻度外周血管疾病患者中。
This study noninvasively measured hemoglobin oxygen saturation in young (n = 6, 28 +/- 6 yrs), old healthy (n = 20, 68 +/- 7 yrs), and old subjects with mild peripheral vascular disease (PVD) (n = 8, 72 +/- 4 yrs). Hemoglobin oxygen saturation was measured as the difference in absorption at 760 and 850 nm light using near-infrared spectroscopy (NIRS). The lateral soleus muscle was studied after mild plantar flexion exercise. The time constant of recovery of oxygen saturation (HBO2Tc) was 21.5 +/- 8.6 s in young, 26.9 +/- 13.5 s in old healthy subjects. PVD subjects had HbO(2)Tc values of 104.4 +/- 41.1 s in their ''bad'' leg and 57.6 +/- 42.2 s in their ''good'' leg. The correlation between HbO(2)Tc and ankle-arm pressures was significant (r(2) = .63, p < .001). Six younger normal, five older normal, and seven PVD subjects also performed a progressive walking test. Normal subjects completed the test without difficulty, and older normal subjects showed progressive deoxygenation. PVD subjects complained of calf pain (4 out of 5 were able to finish) and showed near-maximal deoxygenation throughout the test. In summary, NIRS measurements show promise as a method of evaluating the kinetics of oxygen saturation, particularly in patients with mild peripheral vascular disease.