Amygdala-dependent mechanisms underlying memory retrieval of conditioned taste aversion
Amygdala-dependent mechanisms underlying memory retrieval of conditioned taste aversion
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DOI：
10.1093/chemse/bjh162
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Kobayashi, K
中科院分区：
文献类型：
--
作者：
Yasoshima, Y;Yamamoto, T;Kobayashi, K
条件性味觉厌恶（CTA）是一种联想学习现象，其中新味道食物或流体（条件刺激，CS）的摄取与内脏不适（非条件刺激，US）配对（Yamamoto et al.，1994年）。条件动物避免摄入以前与疾病有关的促味剂。由于CTA是由CS和US的单一配对建立的，因此很容易区分不同的记忆相关阶段：获取，巩固，再巩固和检索。CTA的这种独特性质可用于鉴定和操纵负责每个记忆阶段的潜在生理和分子机制。有大量证据表明杏仁核在CTA的获得和保持中起重要作用（参见，例如，米兰达等人，2003年）。杏仁核接收各种感官输入，包括味觉和内脏信息。它还具有多种递质系统，如多巴胺能、去甲肾上腺素能（NA能）、多巴胺能等神经支配，并含有γ-氨基丁酸（GABA）作为神经递质的抑制性中间神经元。虽然已经有一些关于杏仁核递质系统在CTA采集中的作用的报道，但负责检索的递质系统的功能尚未完全阐明。在本文中，我们总结了我们的研究结果有关杏仁核机制的CTA记忆检索。
Conditioned taste aversion (CTA) is an associative learning phenomenon in which ingestion of a novel tasting food or fluid (conditioned stimulus, CS) is paired with visceral malaise (unconditioned stimulus, US)(Yamamoto et al., 1994). Conditioned animals avoid ingesting the tastant previously associated with the condition of sickness. Since CTA is established by a single pairing of the CS and US, it is easy to distinguish different memory-related phases: acquisition, consolidation, reconsolidation and retrieval. This unique property of CTA is useful in identification and manipulation of the underlying physiological and molecular mechanisms responsible for each memory phase.There is a large amount of evidence that the amygdala plays an important role in the acquisition and retention of CTA (see, for example, Miranda et al., 2003). The amygdala receives a variety of sensory inputs, including gustatory and visceral information. It also has many kinds of transmitter systems, such as glutamatergic, noradrenergic (NAergic), dopaminergic and other innervations, and contains inhibitory interneurons containing γ-aminobutyric acid (GABA) as a neurotransmitter. Although there have been several reports about the roles of amygdalar transmitter systems in CTA acquisition, the functioning of the transmitter systems responsible for the retrieval has not been completely elucidated. In this paper, we summarize our findings regarding amygdalar mechanisms for retrieval of CTA memory.