Simple, distance-based measurement for paper analytical devices
Simple, distance-based measurement for paper analytical devices
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DOI：
10.1039/c3lc50072a
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发表时间：
2013-01-01
期刊：
影响因子：
6.1
通讯作者：
Henry, Charles S.
中科院分区：
文献类型：
--
作者：
Cate, David M.;Dungchai, Wijitar;Henry, Charles S.
基于纸张的分析设备（pad）代表了一种不断增长的优雅，但廉价的化学传感器技术，专为使用点应用而设计。然而，大多数pad仍然使用某种形式的仪器，如相机进行定量检测。我们在这里描述了一种简单的技术，使PAD测量更加定量和直接使用颜色显影距离作为检测母题。与依赖外围设备进行定量测量的传统方法相比，所谓的基于距离的检测使PAD化学物质更加便携，资源密集程度更低。我们展示了该技术的实用性和广泛适用性，分别使用三种不同的检测化学：酶反应、金属络合和纳米颗粒聚集来测量葡萄糖、镍和谷胱甘肽。结果表明，在复杂的样品矩阵中，该方法与认证标准具有良好的定量一致性。这项工作首次展示了基于距离的PAD检测，作为一类为使用点应用而设计的新型廉价传感器技术，具有广泛的应用。
Paper-based analytical devices (PADs) represent a growing class of elegant, yet inexpensive chemical sensor technologies designed for point-of-use applications. Most PADs, however, still utilize some form of instrumentation such as a camera for quantitative detection. We describe here a simple technique to render PAD measurements more quantitative and straightforward using the distance of colour development as a detection motif. The so-called distance-based detection enables PAD chemistries that are more portable and less resource intensive compared to classical approaches that rely on the use of peripheral equipment for quantitative measurement. We demonstrate the utility and broad applicability of this technique with measurements of glucose, nickel, and glutathione using three different detection chemistries: enzymatic reactions, metal complexation, and nanoparticle aggregation, respectively. The results show excellent quantitative agreement with certified standards in complex sample matrices. This work provides the first demonstration of distance-based PAD detection with broad application as a class of new, inexpensive sensor technologies designed for point-of-use applications.