Blunted Rest-Activity Circadian Rhythm Is Associated With Increased Rate of Biological Aging: An Analysis of NHANES 2011-2014.
Blunted Rest-Activity Circadian Rhythm Is Associated With Increased Rate of Biological Aging: An Analysis of NHANES 2011-2014.
复制标题
休息活动昼夜节律迟钝与生物衰老速度加快有关：NHANES 2011-2014 分析。
DOI：
10.1093/gerona/glac199
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Su,Shaoyong
中科院分区：
文献类型：
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作者：
Xu,Yanyan;Wang,Xiaoling;Belsky,DanielW;McCall,WilliamV;Liu,Yutao;Su,Shaoyong
休息-活动昼夜节律受损与发病率和死亡率风险增加有关。时钟基因突变的动物表现出加速衰老和缩短寿命的现象。休息-活动昼夜节律受损是否也与人类衰老过程有关还未被探索。我们分析了参与2011-2014年美国国家健康与营养调查浪潮的7539名成年人的加速度计和生理数据。我们使用加速度计数据来计算休息-活动节律测量值。我们使用生理数据，根据3种已发表的算法计算生物衰老的测量值：klemera - double方法（KDM）、生物年龄、表型年龄和稳态失调（HD）。在调整多个协变量的模型中，相对振幅（RA）和日间稳定性（IS）较高、日内变异性（IV）较低的参与者表现出较低的KDM和PhenoAge指数的生物衰老（这些休息活动测量的1分位数增加的效应大小范围为RA为0.54至0.57“年”，IS为0.24至0.28“年”，IV为0.24至0.35“年”，ps < 0.001）。以HD为指标的生物衰老也有类似的发现，但意义仅限于RA， RA增加1个分位数，HD降低0.09个log单位（p< 0.001）。研究结果表明，在一般人群中，休息-活动昼夜节律的减弱与衰老的加速有关，这表明旨在增强昼夜节律的干预措施可能是延长健康寿命的一种新方法。
Impaired rest–activity circadian rhythm has been associated with increased risk for morbidity and mortality. Animals with mutations in clock genes display accelerated aging and shortened life span. Whether impaired rest–activity circadian rhythm is also associated with processes of aging in humans has not been explored. We analyzed accelerometry and physiological data from 7 539 adults participating in the 2011–2014 waves of the U.S. National Health and Nutrition Examination Surveys. We used accelerometry data to compute rest–activity rhythm measurements. We used physiological data to compute measurements of biological aging according to 3 published algorithms: Klemera–Doubal method (KDM) Biological Age, PhenoAge, and homeostatic dysregulation (HD). In the models adjusting multiple covariates, participants with higher relative amplitude (RA) and interdaily stability (IS) and lower intradaily variability (IV) exhibited less advanced biological aging indexed by KDM and PhenoAge (effect sizes for 1-quantile increase in these rest–activity measurements ranged from 0.54 to 0.57 “years” for RA, 0.24 to 0.28 “years” for IS, and 0.24 to 0.35 “years” for IV,ps < .001). Similar finding was observed for biological aging indexed by HD, but the significance was limited to RA with 1-quantile increase in RA associated with 0.09 log units decrease in HD (p< .001). The results indicate that blunted rest–activity circadian rhythm is associated with accelerated aging in the general population, suggesting that interventions aiming at enhancing circadian rhythm may be a novel approach for the extension of a healthy life span.