Psychological stress can trigger atopic dermatitis in NC/Nga mice: An inhibitory effect of corticotropin-releasing factor
Psychological stress can trigger atopic dermatitis in NC/Nga mice: An inhibitory effect of corticotropin-releasing factor
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DOI：
10.1038/sj.npp.1301435
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发表时间：
2008-02-01
影响因子：
7.6
通讯作者：
Ishikawa, Osamu
中科院分区：
文献类型：
--
作者：
Amano, Hiroo;Negishi, Izumi;Ishikawa, Osamu
特应性皮炎（AD）是最常见的皮肤炎症性疾病之一，通常与特应性素质的家族史有关。许多环境或心理因素会加重AD。然而，目前尚不清楚心理压力本身是否会引发AD。我们研究了心理应激对AD发病的影响，使用动物模型，NC/Nga小鼠。将动物暴露于避水应激（WAS）试验以诱导心理应激。此外，我们研究了促肾上腺皮质激素释放因子（CRF）如何影响心理应激诱导的AD的发展。在无特定病原体（SPF）条件下，NC/Nga小鼠未出现AD样皮肤病变。相比之下，NC/Nga小鼠暴露于心理应激发展AD样皮肤病变沿着血清免疫球蛋白E水平升高，即使保持在SPF条件下。CRF预处理可完全阻断WAS诱导的AD样皮肤病变。我们的数据表明，一个心理因素是能够引起AD样的皮肤病变NC/Nga小鼠。CRF的抑制作用可能是通过具有CRF受体的各种细胞的功能修饰来介导的。
Atopic dermatitis (AD) is one of the most common inflammatory diseases of the skin and is usually associated with a family history of atopic diathesis. It has been well established that many environmental or psychological factors aggravate AD. However, it is not clear whether psychological stress by itself can trigger AD. We examined the effect of psychological stress on the onset of AD, using an animal model, the NC/Nga mouse. The animals were exposed to the water avoidance stress (WAS) test to induce psychological stress. Additionally, we examined how corticotropin-releasing factor (CRF) affected the development of AD induced by psychological stress. Under specific pathogen-free (SPF) conditions, NC/Nga mice did not develop AD-like skin lesions. In contrast, NC/Nga mice exposed to psychological stress developed AD-like skin lesions along with elevated levels of serum immunoglobulin E even when kept under SPF conditions. The AD-like skin lesions induced by WAS were completely blocked by pretreating the animals with CRF. Our data indicate that a psychological factor is capable of eliciting AD-like skin lesions in NC/Nga mice. It is possible that the inhibitory effect of CRF may be mediated by the functional modification of various cells that have CRF receptors.