X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation
X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation
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DOI：
10.1016/s0092-8674(00)81815-2
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发表时间：
1996-12-27
期刊：
影响因子：
64.5
通讯作者：
Pieler, T
中科院分区：
文献类型：
--
作者：
Bellefroid, EJ;Bourguignon, C;Pieler, T
X-MyT1是一种c2hc型锌指蛋白，我们发现它参与了爪蟾神经元前体细胞的初级选择。该基因的表达受bHLH蛋白X-NGNR-1的正调控，并受Notch/Delta信号转导通路的负调控。X-MyT1能够促进异位神经元分化，并对侧抑制不敏感，但仅与bHLH转录因子合作。抑制X-MyT1功能可抑制正常神经发生以及X-NGNR-1过表达引起的异位神经发生。基于这些发现，我们认为X-MyT1在一系列事件中是一个新颖的、必要的元素，这些事件允许细胞逃避侧抑制并进入导致末梢神经元分化的途径。
X-MyT1 is a C2HC-type zinc finger protein that we find to be involved in the primary selection of neuronal precursor cells in Xenopus. Expression of this gene is positively regulated by the bHLH protein X-NGNR-1 and negatively regulated by the Notch/Delta signal transduction pathway. X-MyT1 is able to promote ectopic neuronal differentiation and to confer insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors. Inhibition of X-MyT1 function inhibits normal neurogenesis as well as ectopic neurogenesis caused by overexpression of X-NGNR-1. On the basis of these findings, we suggest that X-MyT1 is a novel, essential element in the cascade of events that allows cells to escape lateral inhibition and to enter the pathway that leads to terminal neuronal differentiation.