On again, off again effects of gonadectomy on the acoustic startle reflex in adult male rats.
On again, off again effects of gonadectomy on the acoustic startle reflex in adult male rats.
复制标题
性腺切除术对成年雄性大鼠听觉惊跳反射的影响。
DOI：
10.1016/j.physbeh.2006.10.010
复制
发表时间：
2007
影响因子：
2.9
通讯作者：
Kritzer,MaryF
中科院分区：
文献类型：
--
作者：
Turvin,JackC;MesserJr,WilliamS;Kritzer,MaryF
大量研究表明，人类和动物的声惊吓反射（ASR）及其前脉冲抑制（PPI）存在性别和/或发情周期差异。然而，很少有人研究激素操纵对这些行为的影响。本研究将成年雄性大鼠的性腺切除术（GDX）与术后2、4、9、16、23、30和37天的ASR和PPI检测配对。对对照组、给予丙酸睾酮的GDX和GDX大鼠的初步研究显示，PPI没有组间差异，但确实显示了GDX大鼠中ASR的阶段性易化，其在第一次和最后一次测试中最大，并且被睾酮减弱。第二项研究探讨了雌激素和雄激素信号传导的作用，测试了新的对照组和GDX大鼠沿着给予雌二醇或非芳香化雄激素5-α-二氢睾酮的GDX大鼠，结果显示PPI没有组间差异，GDX大鼠的ASR增加在第一次和最后一次测试期间最大，并被两种激素替代品减弱。然而，虽然给予睾酮的GDX大鼠的反应与对照组相似，但雌二醇和二氢睾酮治疗的GDX大鼠的ASR通常低于对照组。这可能表明，激素调节的ASR需要协同雌激素和雄激素的作用。在男性大脑中，这可以通过局部类固醇代谢来实现，负责的酶，芳香酶，可以帮助确定在惊吓电路，可能是特别相关的激素调节观察位点。
Numerous studies have shown sex and/or estrous cycle differences in the acoustic startle reflex (ASR) and its prepulse inhibition (PPI) in humans and animals. However, few have examined the effects of hormone manipulations on these behaviors. This study paired gonadectomy (GDX) in adult male rats with testing for ASR and PPI at 2, 4, 9, 16, 23, 30 and 37 days after surgery. Initial studies of control, GDX and GDX rats given testosterone propionate revealed no group differences in PPI, but did reveal phasic facilitation of the ASR in GDX rats that was greatest on the first and final testing sessions and that was attenuated by testosterone. A second study addressing roles for estrogen and androgen signaling tested new control and GDX rats along with GDX rats given estradiol or the non-aromatizable androgen, 5-alpha-dihydrotestosterone and revealed no group differences in PPI, and increases in ASR in GDX rats that were largest during the first and final testing sessions and that were attenuated by both hormone replacements. However, while responses in GDX rats given testosterone were similar to those of controls, ASR in estradiol- and to a lesser extent in dihydrotestosterone-treated GDX rats were typically lower than in controls. This may suggest that hormone modulation of the ASR requires synergistic estrogen and androgen actions. In the male brain where this can be achieved by local steroid metabolism, the enzymes responsible, e.g., aromatase, could help identify loci in the startle circuitry that may be especially relevant for the hormone modulation observed.