Elevated IgG4 concentrations in serum of patients with Mikulicz's disease
Elevated IgG4 concentrations in serum of patients with Mikulicz's disease
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DOI：
10.1080/03009740410006439
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发表时间：
2004-11-01
影响因子：
2.1
通讯作者：
Imai, K
中科院分区：
文献类型：
--
作者：
Yamamoto, M;Ohara, M;Imai, K
Mikulicz病最近被纳入原发性干燥综合征。这是一种独特的条件，涉及扩大泪腺和唾液腺，特点是很少有自身免疫反应。它对糖皮质激素治疗有反应。对Mikulicz病患者进行IgG组分分析，以确定Mikulicz病和干燥综合征之间的差异。这项研究表明，血清IgG 4浓度升高的患者与Mikulicz病，但不与干燥综合征。
Mikulicz's disease has recently been included within primary Sjogren's syndrome. It is a unique condition involving enlargement of the lacrimal and salivary glands, characterized by few autoimmune reactions. It is responsive to glucocorticoid treatment. Analysis of IgG fractions was performed in patients with Mikulicz's disease in order to determine the differences between Mikulicz's disease and Sjogren's syndrome. The study showed that serum IgG4 concentrations are elevated in patients with Mikulicz's disease, but not in those with Sjogren's syndrome.