Hepatocellular carcinoma in patients with chronic liver disease: A comparison of gadoxetic acid-enhanced MRI and multiphasic MDCT
Hepatocellular carcinoma in patients with chronic liver disease: A comparison of gadoxetic acid-enhanced MRI and multiphasic MDCT
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DOI：
10.1016/j.crad.2011.08.011
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发表时间：
2012-02-01
影响因子：
2.6
通讯作者：
Kim, K. -W.
中科院分区：
文献类型：
--
作者：
Baek, C. -K.;Choi, J. -Y.;Kim, K. -W.
目的：比较钆塞酸增强磁共振成像（MRI）和多相多排计算机断层扫描（MDCT）在慢性肝病患者肝细胞癌（HCC）检测中的诊断性能。 材料和方法：本研究获得机构审查委员会的批准，并获得所有患者的知情同意。患有 73 个 HCC 的 51 名患者（43 名男性，8 名女性；年龄范围 32-80 岁）接受了钆塞酸增强 MRI 和多相 MDCT。两名读者在三个独立的阅读过程中独立分析每张图像。采用替代自由反应受试者工作特征（AFROC）方法来分析诊断准确性。评估阳性和阴性预测值以及敏感性。结果：51 例患者中总共检测到 73 个 HCC。虽然不显着（p > 0.05），但 MDCT 的受试者工作特征曲线下面积为 0.877 和 0.850，动态 MRI 的受试者工作特征曲线下面积为 0.918 和 0.911，动态和肝胆期 MR 图像联合判读的受试者工作特征曲线下面积为 0.905 和 0.918。读者之间的敏感性、特异性以及阳性和阴性预测值的差异没有统计学意义（p > 0.05）。动态和肝胆期 MRI 图像的联合判读在 HCC 病变检测中比 MDCT 更有用
AIM: To compare the diagnostic performances of gadoxetic acid-enhanced magnetic resonance imaging (MRI) and multiphasic multidetector computed tomography (MDCT) in the detection of hepatocellular carcinoma (HCC) in patients with chronic liver disease.MATERIALS AND METHODS: Institutional review board approval was obtained for this study and, informed consent was obtained from all patients. Fifty-one patients (43 men, eight women; age range 32-80 years) with 73 HCCs underwent gadoxetic acid-enhanced MRI and multiphasic MDCT. Two readers independently analysed each image in three separate reading sessions. The alternative free-response receiver operating characteristic (AFROC) method was used to analyse the diagnostic accuracy. Positive and negative predictive values and sensitivity were evaluated.RESULTS: A total of 73 HCCs were detected in 51 patients. Although not significant (p > 0.05), the areas under the receiver operating characteristic curves were 0.877 and 0.850 for MDCT, 0.918 and 0.911 for dynamic MRI, and 0.905 and 0.918 for combined interpretation of dynamic and hepatobiliary phase MR images. Differences in sensitivity, specificity, and positive and negative predictive values between the readers were not statistically significant (p > 0.05). Combined interpretation of dynamic and hepatobiliary phase MRI images was more useful than MDCT in the detection of HCC lesions