Update on Actinobacillus pleuropneumoniae-knowledge, gaps and challenges
Update on Actinobacillus pleuropneumoniae-knowledge, gaps and challenges
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DOI：
10.1111/tbed.12739
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发表时间：
2018-05-01
影响因子：
4.3
通讯作者：
Hennig-Pauka, I.
中科院分区：
文献类型：
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作者：
Sassu, E. L.;Bosse, J. T.;Hennig-Pauka, I.
猪胸膜肺炎由猪呼吸道细菌性病原体胸膜肺炎放射杆菌引起，在世界大多数国家，给受影响的猪群造成了巨大的经济损失。猪急性呼吸窘迫综合征是一种严重的呼吸窘迫综合征，具有极高的致死率。该病原体于1957年首次被描述，从那时起，有关病原体本身及其与宿主相互作用的知识不断增加。这部分是由于实验感染可以在自然宿主中进行研究。然而，事实上，大多数商业猪被这种病原体定殖，阻碍了在实验条件下获得的知识的适用性。此外，有几个因素参与疾病的发展，这些因素往往被单独研究。在DISCONTOLS倡议中，来自科学、工业和诊所的成员交流了他们的专业知识和经验观察，并确定了知识方面的主要差距。本综述总结了已发表的结果和专家意见，在发病机制，流行病学，传播，免疫反应的感染，以及预防，检测和控制的主要手段。突出了仍然有待填补的差距，并讨论了控制这一疾病方面目前和今后的挑战。
Porcine pleuropneumonia, caused by the bacterial porcine respiratory tract pathogen Actinobacillus pleuropneumoniae, leads to high economic losses in affected swine herds in most countries of the world. Pigs affected by peracute and acute disease suffer from severe respiratory distress with high lethality. The agent was first described in 1957 and, since then, knowledge about the pathogen itself, and its interactions with the host, has increased continuously. This is, in part, due to the fact that experimental infections can be studied in the natural host. However, the fact that most commercial pigs are colonized by this pathogen has hampered the applicability of knowledge gained under experimental conditions. In addition, several factors are involved in development of disease, and these have often been studied individually. In a DISCONTOOLS initiative, members from science, industry and clinics exchanged their expertise and empirical observations and identified the major gaps in knowledge. This review sums up published results and expert opinions, within the fields of pathogenesis, epidemiology, transmission, immune response to infection, as well as the main means of prevention, detection and control. The gaps that still remain to be filled are highlighted, and present as well as future challenges in the control of this disease are addressed.