Gap Gene Regulatory Dynamics Evolve along a Genotype Network.
Gap Gene Regulatory Dynamics Evolve along a Genotype Network.
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DOI：
10.1093/molbev/msw013
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发表时间：
2016-05
影响因子：
10.7
通讯作者：
Jaeger J
中科院分区：
文献类型：
--
作者：
Crombach A;Wotton KR;Jiménez-Guri E;Jaeger J
发育基因网络实现了动态的调节机制，这些机制塑造和塑造了有机体。随着进化时间的推移，这些网络的布线会发生变化，但图案化的结果往往会被保留下来，这一现象被称为“系统漂移”。双翅目昆虫的GAP基因网络--参与节段模式--说明了系统漂移。在经典模式生物黑腹果蝇和非模式苍蝇Megaselia Abdita中，GAP基因表达结构域的早期激活和放置显示出显著的数量差异，但最终的图案化输出在两个物种中基本相同。在这个系统漂移的详细建模分析中，我们使用了适合于M.Abdita中GAP基因表达数据的基因电路，并将它们与D.Blackogaster的等效模型集进行了比较。这一比较分析的结果准确地表明了补偿性监管机制如何在两个物种中实现同等的最终模式。我们从“基因网络”的角度讨论了这项工作的更大意义，以及调控网络的结构如何影响进化变化的模式(进化性)。
Developmental gene networks implement the dynamic regulatory mechanisms that pattern and shape the organism. Over evolutionary time, the wiring of these networks changes, yet the patterning outcome is often preserved, a phenomenon known as “system drift.” System drift is illustrated by the gap gene network—involved in segmental patterning—in dipteran insects. In the classic model organism Drosophila melanogaster and the nonmodel scuttle fly Megaselia abdita, early activation and placement of gap gene expression domains show significant quantitative differences, yet the final patterning output of the system is essentially identical in both species. In this detailed modeling analysis of system drift, we use gene circuits which are fit to quantitative gap gene expression data in M. abdita and compare them with an equivalent set of models from D. melanogaster. The results of this comparative analysis show precisely how compensatory regulatory mechanisms achieve equivalent final patterns in both species. We discuss the larger implications of the work in terms of “genotype networks” and the ways in which the structure of regulatory networks can influence patterns of evolutionary change (evolvability).