The retinal determination gene network: from developmental regulator to cancer therapeutic target.
The retinal determination gene network: from developmental regulator to cancer therapeutic target.
复制标题
视网膜决定基因网络：从发育调节因子到癌症治疗靶点
DOI：
10.18632/oncotarget.9394
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发表时间：
2016-08-02
期刊：
影响因子：
--
通讯作者：
Wu G
中科院分区：
文献类型：
--
作者：
Kong D;Liu Y;Liu Q;Han N;Zhang C;Pestell RG;Wu K;Wu G
视网膜决定基因网络（RDGN）在哺乳动物多器官发育中起着至关重要的作用。RDGN调节增殖、分化和自分泌信号通路，并与其他关键信号通路相互作用。RDGN成员如DACH、EYA和SIX的异常表达有助于肿瘤的发生和发展；事实上，RDGN成员的水平是各种癌症类型的临床预后因素。刺激或抑制这些关键成分的活性可以阻断癌细胞增殖，阻止癌症干细胞扩增，甚至逆转EMT过程，从而减轻恶性表型。因此，针对RDGN成员的癌症治疗干预应在未来的研究中继续进行。
Although originally identified for its function in Drosophila melanogaster eye specification, the Retinal Determination Gene Network (RDGN) is essential for the development of multiple organs in mammals. The RDGN regulates proliferation, differentiation and autocrine signaling, and interacts with other key signaling pathways. Aberrant expression of RDGN members such as DACH, EYA and SIX contributes to tumor initiation and progression; indeed, the levels of RDGN members are clinically prognostic factors in various cancer types. Stimulation or suppression of the activities of these crucial components can block cancer cell proliferation, prevent cancer stem cell expansion and even reverse the EMT process, thereby attenuating malignant phenotypes. Thus, cancer therapeutic interventions targeting RDGN members should be pursued in future studies.