Role of granule proteases in the life and death of neutrophils
Role of granule proteases in the life and death of neutrophils
复制标题
DOI：
10.1016/j.bbrc.2016.11.086
复制
发表时间：
2017-01-15
影响因子：
3.1
通讯作者：
Simon, Hans-Uwe
中科院分区：
文献类型：
--
作者：
Benarafa, Charaf;Simon, Hans-Uwe
中性粒细胞构成了先天免疫防御微生物的重要组成部分。中性粒细胞在骨髓中产生并在血管中巡逻，被招募到受伤的组织并立即活跃以遏制病原体入侵。中性粒细胞通过多种环境特异性途径经历程序性细胞死亡，这对免疫病理学和疾病结果具有影响。过去十年的研究表明，中性粒细胞或中性粒细胞的一个子集在调节适应性反应和肿瘤进展中具有额外的功能。中性粒细胞颗粒含有大量的各种蛋白酶，这些蛋白酶直接参与中性粒细胞的保护和致病功能。现在出现的是中性丝氨酸蛋白酶如组织蛋白酶G和蛋白酶-3也有助于嗜中性粒细胞的生命周期，但通过与天冬氨酸蛋白酶组织蛋白酶D和丝氨酸蛋白酶弹性蛋白酶突变体不同的途径来这样做。本文综述了中性粒细胞颗粒蛋白酶及其抑制剂在中性粒细胞死亡中的作用，并将这些研究结果与目前对中性粒细胞生命周期和程序性细胞死亡途径的认识相结合。(C)2016 Elsevier Inc. All rights reserved.
Neutrophils constitute a crucial component of the innate immune defenses against microbes. Produced in the bone marrow and patrolling in blood vessels, neutrophils are recruited to injured tissues and are immediately active to contain pathogen invasion. Neutrophils undergo programmed cell death by multiple, context-specific pathways, which have consequences on immunopathology and disease outcome. Studies in the last decade indicate additional functions for neutrophils - or a subset of neutrophils in modulating adaptive responses and tumor progression. Neutrophil granules contain abundant amounts of various proteases, which are directly implicated in protective and pathogenic functions of neutrophils. It now emerges that neutral serine proteases such as cathepsin G and proteinase-3 also contribute to the neutrophil life cycle, but do so via different pathways than that of the aspartate protease cathepsin D and that of mutants of the serine protease elastase. The aim of this review is to appraise the present knowledge of the function of neutrophil granule proteases and their inhibitors in neutrophil cell death, and to integrate these findings in the current understandings of neutrophil life cycle and programmed cell death pathways. (C) 2016 Elsevier Inc. All rights reserved.