Age of onset as a risk factor of renal involvement in Henoch-Schönlein purpura.
Age of onset as a risk factor of renal involvement in Henoch-Schönlein purpura.
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DOI：
10.5415/apallergy.2014.4.1.42
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发表时间：
2014-01
影响因子：
1.7
通讯作者：
Setiabudiawan B
中科院分区：
文献类型：
--
作者：
Ghrahani R;Ledika MA;Sapartini G;Setiabudiawan B
过敏性紫癜（HSP）是儿童最常见的血管炎，其特征是三联征：可触及的紫癜无血小板减少症、腹痛和关节炎。HSP儿童经常发生肾脏受累。没有关于印度尼西亚（尤其是西爪哇）HSP儿童肾脏受累的数据。目的探讨过敏性紫癜患儿肾脏损害的特点。对2006年至2011年在Hasan Sadikin医院儿童保健科的HSP儿童进行了回顾性研究。回顾性分析其临床表现及特征。HSP的诊断标准为美国风湿病学会1990年标准或欧洲抗风湿病联盟/小儿风湿病国际试验组织/小儿风湿病欧洲学会2008年标准。共有128例患者，其中男性82例（64.9%），女性46例（35.1%），比例为1.8：1。平均年龄为7.9 ± 2.9岁，范围为6个月至15岁。发病高峰在5-10岁之间。Hasan Sadikin医院的HSP患病率从2008年的2.7/100 000上升到2010年的5.2/100 000。多数患者（71%）以紫癜为首发症状。关节炎71例（44.5%），腹痛89例（69.5%），肾脏受累28例（21.8%）。胃肠道表现倾向于出现在小于5岁的患者中（p = 0.267），而肾脏受累倾向于出现在11-15岁的年龄组中（p = 0.015），比值比为3.1（95%置信区间，1.2-8.1）。HSP患儿肾脏受累在11 ~ 15岁年龄组较为常见。
Henoch-Schönlein purpura (HSP) is the most common vasculitis in children, characterized by triad of symptoms; palpable purpura without thrombocytopenia, abdominal pain, and arthritis. Renal involvement often occur in children with HSP. No data on the renal involvement of children with HSP in Indonesia, especially West Java. To evaluate renal involvement in children with HSP. Retrospective study was conducted in children with HSP in Department of Child Health, Hasan Sadikin Hospital, from 2006 to 2011. Characteristics and clinical manifestations was reviewed from medical record. HSP was diagnosed by American College of Rheumatology 1990 criteria or European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society 2008. There were 128 patients, consisting of 82 male (64.9%) and 46 female (35.1%) with ratio 1.8:1. Mean age was 7.9 ± 2.9 years old which range from 6 month to 15 years. Peak morbidity was between 5-10 years old. Prevalence of HSP in Hasan Sadikin Hospital tend to raise from 2.7/100,000 in 2008 to 5.2/100,000 in 2010. In most patients (71%) purpura was the first symptom. Seventy-one patients (44.5%) had arthritis and 89 patients (69.5%) had abdominal pain, while renal involvement was in 28 patients (21.8%). Gastrointestinal manifestations tend to manifest in patients less than 5 years old (p = 0.267), while renal involvement tend to manifest in age group 11-15 years old (p = 0.015) with odds ratio 3.1 (95% confidence interval, 1.2-8.1). Renal involvement in children with HSP is more common in age group 11 to 15 years old.