Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003-2005)
Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003-2005)
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DOI：
10.2460/javma.232.4.553
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发表时间：
2008-02-15
影响因子：
1.9
通讯作者：
Pesillo-Crosby, S. Anna
中科院分区：
文献类型：
--
作者：
Hammond, Tara N.;Pesillo-Crosby, S. Anna
目的：确定脾肿块和血性腹水需输血的贫血犬的脾血管肉瘤的患病率，并找出入院时血管肉瘤犬与其他脾肿块的犬之间的区别因素。设计：回顾性病例系列。动物71只。过程-2003年至2005年，需要输血的脾肿块和血性腹膜贫血犬的医疗记录、血库记录和组织学报告。接受填充红细胞输注的狗，接受脾切除，并有明确的组织学诊断的狗包括在内。结果-狗的信号与其他报道相似。71只犬中54只(76.1%)出现恶性脾肿瘤，17只(23.9%)为良性病变。在54只患恶性脾肿瘤的犬中，50只(92.6%，占全部犬的70.4%)出现了脾血管肉瘤。此外，患脾血管肉瘤的狗在入院时总固体(TS)浓度和血小板计数显著降低。最后，血腹膜与脾血管肉瘤的诊断密切相关。结论和临床相关性--在这个临床种群中，血管肉瘤的患病率高于其他研究。与其他脾肿块的狗相比，本研究中患有血管肉瘤的狗在入院时TS浓度和血小板计数显著降低。没有其他标记物可用于区分狗的血管肉瘤。当业主考虑是否继续治疗时，与他们讨论与血管肉瘤相关的发病率和不良预后是很重要的。
Objective-To determine prevalence of splenic hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion and to identify factors that could differentiate between dogs with hemangiosarcoma and dogs with other splenic masses at the time of hospital admission.Design-Retrospective case series.Animals-71 dogs.Procedures-Medical records, blood bank logs, and histologic reports of dogs with a splenic mass and hemoperitoneum that required a transfusion between 2003 and 2005 were reviewed. Dogs that received a transfusion of packed RBCs, were splenectomized, and had a definitive histologic diagnosis were included.Results-Signalment of dogs was similar to that in other reports. Malignant splenic neoplasia was identified in 54 of 71 (76.1 %) dogs, whereas 17 of 71 (23.9%) dogs had a benign splenic lesion. Of 54 dogs with malignant splenic neoplasia, 50 (92.6% [70.4% of all dogs]) had splenic hemangiosarcoma. In addition, dogs with splenic hemangiosarcoma had significantly lower total solids (TS) concentrations and platelet counts at admission. Finally, hemoperitoneum was strongly associated with a diagnosis of splenic hemangiosarcoma.Conclusions and Clinical Relevance-In this clinical population of dogs, prevalence of hemangiosarcoma was higher than in other studies. Dogs with hemangiosarcoma in this study had significantly lower TS concentrations and platelet counts at the time of admission, compared with values for dogs with other splenic masses. No other markers were useful in differentiating dogs with hemangiosarcoma. It is important to discuss the prevalence of and poor prognosis associated with hemangiosarcoma with owners when they are contemplating whether to proceed with treatment.