Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen
Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen
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DOI：
10.4103/0019-509x.55551
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发表时间：
2009-10-01
影响因子：
1
通讯作者：
Seam, R. K.
中科院分区：
文献类型：
--
作者：
Arora, R.;Thakur, J. S.;Seam, R. K.
背景：顺铂引起的耳毒性表现出较高的个体差异，并且通常伴有短暂或永久性耳鸣。在开始治疗之前不可能识别易感个体。我们在三级医疗中心进行了一项前瞻性、随机和观察性研究，评估了不同剂量的顺铂对听力的影响。材料和方法：本研究纳入了 57 名计划接受顺铂化疗的患者。根据3周内顺铂输注剂量将所有患者分为三组。结果：7例患者出现主观听力损失，6例患者化疗期间出现耳鸣。听力损失是感音神经性的、剂量依赖性的、对称的、双侧的和不可逆的。较高的频率首先受到顺铂化疗的影响。结论：由于高频测听的使用仍仅限于研究工作，因此我们需要在顺铂化疗方案中添加高频测听的严格方案。
BACKGROUND: Cisplatin-induced ototoxicity shows high interindividual variability and is often accompanied by transient or permanent tinnitus. It is not possible to identify the susceptible individuals before commencement of the treatment. We conducted a prospective, randomized and observational study in a tertiary care centre and evaluated the effects of different doses of cisplatin on hearing. MATERIALS AND METHODS: Fifty-seven patients scheduled for cisplatin-based chemotherapy were included in the study. All patients were divided into three groups depending on the dose of cisplatin infused in 3 weeks. RESULTS: The subjective hearing loss was found in seven patients, while six patients had tinnitus during the chemotherapy. The hearing loss was sensorineural, dose dependent, symmetrical, bilateral and irreversible. Higher frequencies were first to be affected in cisplatin chemotherapy. ConClusion: As use of high-frequency audiometry is still limited in research work only, we need a strict protocol of adding high-frequency audiometry in the cisplatin-based chemotherapy regimen.