ACTION-POTENTIAL MUTATIONS STOP A BIOLOGICAL CLOCK IN DROSOPHILA
ACTION-POTENTIAL MUTATIONS STOP A BIOLOGICAL CLOCK IN DROSOPHILA
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DOI：
10.1038/314171a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
HALL, JC
中科院分区：
文献类型：
--
作者：
KYRIACOU, CP;HALL, JC
果蝇雄性通过振动翅膀产生一种种特定的求偶歌。鸣唱最显著的特征是一系列脉冲，脉冲间间隔（IPI）为30-40 ms [1，2]，野生型雄性鸣唱的周期为50-60 s（参考文献3）。IPI中的这种短期生物节律受到period（per）位点的几个基因突变的影响，这些基因突变改变了生物钟正常的24小时自由运行周期4，并对歌曲周期3产生相应的影响。目前的研究表明，在限制条件下，温度敏感的突变，影响神经元膜的兴奋性似乎停止生物钟的果蝇的歌曲节奏。
TheDrosophila melanogastermale produces a species-specific courtship song by wing vibration. The most conspicuous feature of the song is a series of pulses with a 30–40-ms interpulse interval (IPI)1,2which oscillate in wild-type males with a period of 50–60 s (ref. 3). This short-term biological rhythm in IPI is influenced by several gene mutations at theperiod(per) locus, which alter the normal 24-h free-running period of the circadian clock4and have corresponding effects on the song cycle3. The present study reveals that, under restrictive conditions, temperature-sensitive mutations which affect neuronal membrane excitability seem to stop the biological clock underlying the fruitfly's song rhythm.