A one year study of the macular pigment: The effect of 140 days of a lutein supplement
A one year study of the macular pigment: The effect of 140 days of a lutein supplement
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DOI：
10.1006/exer.1997.0309
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发表时间：
1997-07-01
影响因子：
3.4
通讯作者：
Sprague, KE
中科院分区：
文献类型：
--
作者：
Landrum, JT;Bone, RA;Sprague, KE
低密度的黄斑色素可能是老年性黄斑变性(AMD)的危险因素，因为它允许更大的蓝光损伤。本研究旨在探讨日粮中添加叶黄素对黄斑色素光密度的影响。两名受试者每天摄入相当于30毫克游离叶黄素的叶黄素酯，持续140天。在补充期前、补充期中和补充期后用异色闪烁光度法测定黄斑色素的光密度。用高效液相色谱法对血样进行分析，得到血清中叶黄素浓度。在开始服用叶黄素补充剂20至40天后，他们的黄斑色素光密度开始以平均1.13+/-0.12毫安吸光单位/天的速度均匀增加。在此期间，血清叶黄素浓度增加了大约10倍，接近稳定状态平台，光密度曲线在受试者停止补充后40-50天最终趋于平稳，在同样的40-50天内，血清浓度恢复到基线水平。此后，几乎没有观察到光密度的下降。两组受试者黄斑色素平均光密度分别增加39%和21%。总而言之，据估计，在适度的补充期内，受试者到达光感受器、Bruchs膜和视网膜色素上皮的蓝光减少了30%到40%，这些都是受AMD影响的脆弱组织。(C)1997年学术出版社有限公司。
A low density of macular pigment may represent a risk factor for age-related macular degeneration (AMD) by permitting greater blue light damage. This study was carried out to determine the effects on macular pigment optical density of dietary supplementation with lutein, one of the pigment constituents. Two subjects consumed lutein esters, equivalent to 30 mg of free lutein per day, for a period of 140 days. Macular pigment optical density was determined by heterochromatic flicker photometry before, during, and after the supplementation period. Serum lutein concentration was also obtained through the analysis of blood samples by high-performance liquid chromatography. Twenty to 40 days after the subjects commenced taking the lutein supplement, their macular pigment optical density began to increase uniformly at an average rate of 1.13 +/- 0.12 milliabsorbance units/day. During this same period, the serum concentration of lutein increased roughly tenfold, approaching a steady state plateau, The optical density curve eventually levelled off 40 to 50 days after the subjects discontinued the supplement, During the same 40 to 50 days, the serum concentration returned to baseline. Thereafter, little or no decrease in optical density was observed. The mean increases in the macular pigment optical density were 39% and 21% in the eyes of the two subjects respectively. In conclusion, the modest period of supplementation has been estimated to have produced in the subjects a 30 to 40% reduction in blue light reaching the photoreceptors, Bruch's membrane, and the retinal pigment epithelium, the vulnerable tissues affected by AMD. (C) 1997 Academic Press Limited.